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GDI1 Antibody

  • 货号：
    CSB-PA004641
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using GDI-1 Polyclonal Antibody
  • 其他：

产品详情

  • 产品描述：

    The GDI1 antibody is generated by immunizing rabbits with the synthesized peptide derived from the C-terminal domain of the human GDI1 protein. It is a polyclonal antibody and exists as an unconjugated IgG. It can cross-react with human, mouse, and rat GDI1 protein. And it has undergone affinity purification from rabbit anti-serum by affinity-chromatography using epitope-specific immunogen. Quality tests of this antibody in WB and ELISA have been validated. The target protein GDI1, expressed primarily in neural and sensory tissues, is a regulator of the Rab small G proteins implicated in neurotransmission, and mutations of Rab GDIα cause human X-linked mental retardation associated with epileptic seizures.

  • Uniprot No.：
    P31150
  • 基因名：
    GDI1
  • 别名：
    1A antibody; FLJ41411 antibody; GDI-1 antibody; gdi1 antibody; GDIA_HUMAN antibody; GDIL antibody; GDP dissociation inhibitor 1 antibody; Guanosine diphosphate dissociation inhibitor 1 antibody; Mental retardation X-linked 41 antibody; Mental retardation X-linked 48 antibody; MRX41 antibody; MRX48 antibody; Oligophrenin 2 antibody; Oligophrenin-2 antibody; OPHN2 antibody; Protein XAP 4 antibody; Protein XAP-4 antibody; Protein XAP4 antibody; Rab GDI alpha antibody; Rab GDP dissociation inhibitor alpha antibody; RABGD1A antibody; RABGDIA antibody; XAP 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human GDI-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
  • 基因功能参考文献：
    1. Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA (human, human recombinant, or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA. PMID: 25346144
    2. Human oligodendrogliomas cells stably expressing mutant GDI1 showed altered cell proliferation. PMID: 25694352
    3. The results of this study identified RabGDI as a component of the switching mechanism that is required for commissural axons to change their response from attraction to repulsion at the intermediate target PMID: 23140504
    4. GDI1 mutations cause an unspecific phenotype characterized by cognitive deficits of variable degree in males, and to a lesser degree in female carriers. PMID: 22002931
    5. The mutations in this gene are common and do not seem to influence the gene expression so as to cause a change in phenotype. PMID: 21736009
    6. A model by which mutant PrP induces overexpression of GDI, activating a cytotoxic feedback loop that leads to protein accumulation in the secretory pathway. PMID: 19996123
    7. RhoGDI has a role in inactivating Rho GTPases with ExoS RhoGAP PMID: 15292224
    8. isoprenylcysteine carboxylmethyltransferase regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI through TNFA PMID: 15647276
    9. RhoGDI overexpression is associated with paclitaxel resistance in ovarian cancers PMID: 16596196
    10. The results of case-control analysis indicated that, no association between the rs11549300 polymorphisms of GDI1 and children NSMR (P >0.05), but its polymorphisms may be related to intelligence levels of children in Qinba region (P =0.03). PMID: 18487148
    11. GDI-1 is preferentially involved in insulin-stimulated glucose transporter 4 (GLUT4) translocation through facilitating Rab10 recycling. PMID: 19570034

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  • 相关疾病：
    Mental retardation, X-linked 41 (MRX41)
  • 亚细胞定位：
    Cytoplasm. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Rab GDI family
  • 组织特异性：
    Brain; predominant in neural and sensory tissues.
  • 数据库链接：

    HGNC: 4226

    OMIM: 300104

    KEGG: hsa:2664

    STRING: 9606.ENSP00000394071

    UniGene: Hs.595950