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GDF7 Antibody

  • 货号：
    CSB-PA768769LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate
      All lanes: GDF7 antibody at 7.9µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47 kDa
      Observed band size: 47 kDa
    • IHC image of CSB-PA768769LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA768769LA01HU diluted at 1:300 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GDF7 Polyclonal antibody
  • Uniprot No.：
    Q7Z4P5
  • 基因名：
  • 别名：
    bmp12 antibody; bone morphogenetic protein 12 antibody; GDF-7 antibody; Gdf7 antibody; GDF7_HUMAN antibody; growth differentiation factor 7 antibody; Growth/differentiation factor 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Growth/differentiation factor 7 protein (322-450AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GDF7 Antibody (CSB-PA768769LA01HU)，的标记方式是Non-conjugated。对于GDF7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA768769LB01HU GDF7 Antibody, HRP conjugated ELISA
    FITC CSB-PA768769LC01HU GDF7 Antibody, FITC conjugated
    Biotin CSB-PA768769LD01HU GDF7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play an active role in the motor area of the primate neocortex.
  • 基因功能参考文献：
    1. BMP-12 activates tenogenic pathway in human adipose stem cells. PMID: 28214472
    2. The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. PMID: 26783083
    3. closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development PMID: 25447851
    4. BMP12 induces tenogenic differentiation of adipose-derived stromal cells via the Smad1/5/8 pathway. PMID: 24155967
    5. studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers PMID: 21702718
    6. induces ligamentogenic differentiation in mesenchymal progenitors PMID: 20334610
    7. stimulates expression of both chondrogenic and osteoblstic markers in pluripotent mesenchymal C3H10T1/2 cells. PMID: 20102312
    8. In mouse, the expression of Gdf7 in roof plate cells is required for the fidelity of commissural axon growth. PMID: 12741987

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 数据库链接：

    HGNC: 4222

    OMIM: 604651

    KEGG: hsa:151449

    STRING: 9606.ENSP00000272224

    UniGene: Hs.447688