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GDE1 Antibody

  • 货号：
    CSB-PA009341GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NZC3
  • 基因名：
    GDE1
  • 别名：
    GDE1 antibody; MIR16Glycerophosphodiester phosphodiesterase 1 antibody; EC 3.1.4.- antibody; EC 3.1.4.44 antibody; Membrane-interacting protein of RGS16 antibody; RGS16-interacting membrane protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GDE1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol. Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and partipates to bioactive N-acylethanolamines biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity. Has little or no activity towards glycerophosphocholine.
  • 基因功能参考文献：
    1. Study demonstrated that puerarin could inhibit cell proliferation, promote cell apoptosis, and deactivate NF-kappaB signaling pathway via upregulation of miR-16 in T24 cells PMID: 29422113
    2. MiR15a/16 inhibited the components of TGF-beta signaling pathways. PMID: 29803177
    3. Our outcomes suggest that miR-15a/16 maintain the retinal endothelial cell barrier by reducing TGFbeta3/VEGF signaling and increasing levels of key tight junction proteins. PMID: 28774775
    4. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. PMID: 29087386
    5. we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects. PMID: 27157613
    6. miR-15a/16 may function as a tumor suppressor in MM through multiple regulatory mechanisms PMID: 27596960
    7. The expression levels of two target genes, Myb and VEGFR2, were affected significantly by miR-16, while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration. PMID: 26934556
    8. Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells. PMID: 26061016
    9. Our data indicate differential concentrations of plasma miR-16, miR-107, miR-130a and miR-146a in different breast cancer subtypes, suggesting a potential role of these miRs in breast cancer biology and tumor progression. PMID: 26033453
    10. miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress. PMID: 24336073
    11. Up-regulation of miR-16 is associated with triple negative breast cancer. PMID: 23405235
    12. This study demonistrated that miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. PMID: 22463747
    13. miR-16 and miR-21 are directly regulated by the transcription factor NF-kappaB and yet nicotine-promoted cell proliferation is mediated via EP2/4 receptors. PMID: 21081469
    14. Results suggest an important role of miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis. PMID: 20668064
    15. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions in patients with multiple myeloma PMID: 20031211
    16. regulation by by stimulation of G protein-coupled receptors PMID: 12576545
    17. Glycerophosphodiesterase has robust activity on glycerophospho-N-acyl ethanolamines (GP-NAEs) which are precursors for the N-acyl ethanolamines including the endocannabinoid anandamide. Thus, GDE1 may participate in anandamide biosynthesis. PMID: 18227059

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glycerophosphoryl diester phosphodiesterase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 29644

    OMIM: 605943

    KEGG: hsa:51573

    STRING: 9606.ENSP00000261386

    UniGene: Hs.512607