Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. GBA3 Antibody

GBA3 Antibody

  • 货号：
    CSB-PA001337
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using CBG Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9H227
  • 基因名：
    GBA3
  • 别名：
    CBG antibody; CBGL1 antibody; Cytosolic beta glucosidase antibody; Cytosolic beta glucosidase like protein 1 antibody; Cytosolic beta-glucosidase antibody; Cytosolic beta-glucosidase-like protein 1 antibody; GBA3 antibody; GBA3_HUMAN antibody; GLUC antibody; Glucosidase beta acid 3 antibody; Klotho related protein antibody; KLRP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CBG.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics. Could also play a role in the catabolism of cytosolic sialyl free N-glycans.
  • 基因功能参考文献：
    1. cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein PMID: 26193330
    2. No correlation was observed between GBA3 1368A/T haplotypes and severity of type 1 Gaucher disease manifestation PMID: 20728381
    3. The positioning of a substrate molecule (quercetin-4'-glucoside) by homology modelling revealed that hydrophobic interactions dominate the binding of the aglycone moiety. PMID: 17555766
    4. The crystal structure of a covalent intermediate of the KLrP mutant E165Q, in which glucose was covalently bound to a nucleophile, Glu(373), is reported. PMID: 18662675
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Glycosyl hydrolase 1 family, Klotho subfamily
  • 组织特异性：
    Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.
  • 数据库链接：

    HGNC: 19069

    OMIM: 606619

    KEGG: hsa:57733

    STRING: 9606.ENSP00000471397

    UniGene: Hs.653107