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GATA4 Antibody

  • 货号：
    CSB-PA070437
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA070437(GATA4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P43694
  • 基因名：
  • 别名：
    ASD2 antibody; GATA 4 antibody; GATA binding protein 4 antibody; GATA-binding factor 4 antibody; gata4 antibody; GATA4_HUMAN antibody; MGC126629 antibody; Transcription factor GATA 4 antibody; Transcription factor GATA-4 antibody; Transcription factor GATA4 antibody; VSD1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human GATA4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase.
  • 基因功能参考文献：
    1. The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2. PMID: 29972125
    2. direct binding of GATA4 to the GNAI3 promoter, both in vitro and in vivo, is reported. PMID: 28484278
    3. Report a genome-wide association scan of 466 bicuspid aortic valve cases and 4,660 age, sex and ethnicity-matched controls with replication in up to 1,326 cases and 8,103 controls. We identify association with a noncoding variant 151 kb from the gene encoding the cardiac-specific transcription factor, GATA4, and near-significance for p.Ser377Gly in GATA4. PMID: 28541271
    4. GATA4 variants were not associated with Alcohol Use Disorder (AUD) in either the European ancestry or African ancestry groups after correcting for multiple comparisons. Rs10112596 demonstrated a significant relationship with an anxiety measure among the African ancestry group with AUD. PMID: 29415147
    5. High GATA4 expression is associated with mesenchymal and migratory phenotype of hepatoblastoma cells. PMID: 30074440
    6. GATA4 may inhibit diabetesinduced endothelial dysfunction by acting as a transcription factor for NOX4 expression. PMID: 29138836
    7. GATA4 acetylation activated CCND2 transcription, and mutation of GATA4 on K-313 reduced cell viability and increased a mitochondria-dependent apoptosis. PMID: 29590644
    8. we found two nucleotide deletions which one of them was novel and one new indel mutation resulting in frame shift mutation, and 4 synonymous variations or polymorphism in 6 of patients and 3 of normal individuals PMID: 29377543
    9. the mutation significantly diminished the synergistic activation between MEF2C and GATA4, another cardiac core transcription factor that has been causally linked to Congenital heart disease (CHD). PMID: 29104469
    10. GATA4 was a transcription factor that activated mouse double minute 2 homolog (MDM2) and B cell lymphoma 2 (BCL2) expression in ALL cells. PMID: 28849107
    11. This report demonstrates that GATA4 promotes oncogenesis by inhibiting miR125b-dependent suppression of DKK3 expression. This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells. PMID: 27788486
    12. study found that the formation of pancreatic progenitors cells is highly sensitive to the GATA6 and GATA4 gene dosage PMID: 28196600
    13. when ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4. PMID: 29018978
    14. GATA4 is a regulator of osteoblastic differentiation via the p38 signaling pathways. PMID: 28393293
    15. miR-126 inhibits the migration and invasion of glioma cells, which may be linked to GATA4 as a target gene. PMID: 27598297
    16. Study identified effects of GATA4 variant [(SNP) rs13273672] on regional gray matter (GM) volume in alcohol dependence: higher GM volume in the hypothalamus and caudate in the AA genotype group compared to the AG/GG group. GM volume specific to GATA4 variant predicted heavy relapse risk within 60 d following discharge for both caudate and amygdala and within 90 d for the amygdala only. PMID: 27397865
    17. The role of GATA4 was elucidated in alcohol dependence susceptibility by identifying rare genetic variants. PMID: 27374936
    18. disruption of GATA4-mediated transactivation in hepatocellular carcinoma suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype PMID: 28758902
    19. This study attempts to correlate the pattern of intronic variants of GATA4 gene which might provide new insights to unravel the possible molecular etiology of congenital heart disease. PMID: 28843068
    20. GATA4 induces autocrine BMP2 signaling in endothelial cells PMID: 28669928
    21. study identified a novel mutation in GATA4 that likely contributed to the Congenital Heart Disease in this family. This finding expanded the spectrum of GATA4 mutations and underscored the pathogenic correlation between GATA4 mutations and Congenital Heart Disease. PMID: 27391137
    22. Hence, the variant distribution of NKX2-5, GATA4 and TBX5 are tightly associated with particular Congenital heart disease subtypes. Further structure-modelling analysis revealed that these mutated amino acid residuals maintain their DNA-binding ability and structural stability PMID: 27426723
    23. Findings suggest that a single introduction of the three cardiomyogenic transcription factor (GATA4, cand TBX5)genes using polyethyleneimine (PEI)-based transfection is sufficient for transdifferentiation of adipose-derived stem cells (hADSCs) towards the cardiomyogenic lineage. PMID: 27553283
    24. Meta-analysis suggested that GATA4 99 G>T and 487 C>T mutations may not be related to the incidence of congenital heart disease (CHD). However, GATA4 354 A>C mutation was significantly associated with CHD risk. PMID: 28471988
    25. common variants in 3'UTR of the GATA4 gene jointly interact, affecting the congenital heart disease susceptibility, probably by altering microRNA posttranscriptional regulation PMID: 27118528
    26. Our studies suggest that GATA5 but especially GATA4 are main contributors to SCN5A gene expression, thus providing a new paradigm of SCN5A expression regulation that may shed new light into the understanding of cardiac disease. PMID: 27894866
    27. GATA4-G296S mutation led to failure of GATA4 and TBX5-mediated repression at non-cardiac genes and enhanced open chromatin states at endothelial/endocardial promoters. These results reveal how disease-causing missense mutations can disrupt transcriptional cooperativity, leading to aberrant chromatin states and cellular dysfunction, including those related to morphogenetic defects. PMID: 27984724
    28. We confirmed the significance of the HNF1B and GATA4 hypermethylation with emphasis on the need of selecting the most relevant sites for analysis. We suggest selected CpGs to be further examined as a potential positive prognostic factor. PMID: 28241454
    29. our results indicate that since high endogenous levels of transcription factor GATA4 likely protect hepatoblastoma cells from doxorubicin-induced apoptosis, these cells can be rendered more sensitive to the drug by downregulation of GATA4. PMID: 28349834
    30. Subsequent functional analyses revealed that the transcriptional activity and Western blot of A167D mutant GATA4 protein were not altered in a Chinese Han population. These variants may be involved in other mechanisms underlying Conotruncal heart defect (CTD) or may be unrelated to CTD occurrence. PMID: 28161810
    31. Study demonstrated downregulation of expression of pancreatic master genes SOX9, FOXA2, and GATA4 (2-, 5-, and 4-fold, respectively) and in PANC1 pancreatic cancer cell line stimulated with TGFbeta1 PMID: 27599506
    32. Mutations of GATA4 appear to be responsible for some cardiac septal defects. The aim of this work was to screen for mutations in the GATA4 gene in sample of Egyptian patients affected by isolated and non-isolated cardiac septal defects. Identified are two coding variants and four non-coding ones of GATA4 gene, but further confirmation study for familial segregation detection was recommended. PMID: 27064867
    33. The definitive endoderm and foregut endoderm differentiation capabilities of Wnt pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 and FOXA2 and those of the transcription activator GATA4 and the alpha-fetoprotein (AFP) gene, respectively. PMID: 26861571
    34. NKX2.5 and GATA4 gene mutations might participate in the development of congenital heart disease and can promote bone marrow derived stroma cell differentiate into cardiomyocytes. PMID: 27154817
    35. There was no evidence of a role for NKX2-5 and GATA4 CNV in fetal CHD; therefore, these CNV may not be common in fetal CHD in China PMID: 25203927
    36. results demonstrate that cGMP-PKG signaling mediates transcriptional activity of GATA4 and links defective GATA4 and PKG-1alpha mutations to the development of human heart disease. PMID: 26946174
    37. This study showed that GATA4 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. PMID: 26381449
    38. Kaplan-Meier survival analysis revealed significantly shorter overall survival in pediatric Acute myeloid leukemia with GATA4 promoter methylation but multivariate analysis shows that it is not an independent factor. PMID: 26490736
    39. Data show that the combination of GATA binding protein 4 (Gata4), T-box transcription factor 5 (Tbx5) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes. PMID: 26071180
    40. we identified a mutation in the GATA4 Kozak sequence that likely contributes to the pathogenesis of Atrial septal defect. PMID: 25099673
    41. Whole exome sequencing results on four-generation Chinese family with atrial septal defect (ASD) identified a novel mutation in GATA4 gene at the methylation position associated with ASD. PMID: 26376067
    42. this study confirms that GATA4 M310V mutation may lead to the development of the congenital heart defect, ASD. PMID: 25873328
    43. Germline mutations in the NKX2-5, GATA4, and CRELD1 genes do not appear to be associated with CHD in Mexican DS patients. PMID: 25524324
    44. No copy number variations of the gene were detected. GST pull-down assays demonstrated that all potentially deleterious variants, including those previously reported, did not impair the interaction with GATA4 PMID: 25025186
    45. The present study is the first to suggest that GATA-4 gene methylation status may independently predict health status in individuals with COPD. PMID: 24973415
    46. GATA4 accumulates in multiple tissues, including the aging brain, and could contribute to aging and its associated inflammation. PMID: 26404840
    47. GATA4 genetic variations are associated with congenital heart disease PMID: 25928801
    48. KLF5/GATA4/GATA6 may promote gastric cancer development by engaging in mutual crosstalk, collaborating to maintain a pro-oncogenic transcriptional regulatory network in gastric cancer cells. PMID: 25053715
    49. NEXN as a novel gene for ASD and its function to inhibit GATA4 established a critical regulation of an F-actin binding protein on a transcription factor in cardiac development PMID: 24866383
    50. Early cardiac marker gene GATA4 levels in peripheral blood mononuclear cells reflect severity in stable coronary artery disease. PMID: 24681789

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  • 相关疾病：
    Atrial septal defect 2 (ASD2); Ventricular septal defect 1 (VSD1); Tetralogy of Fallot (TOF); Atrioventricular septal defect 4 (AVSD4); Testicular anomalies with or without congenital heart disease (TACHD)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 4173

    OMIM: 187500

    KEGG: hsa:2626

    STRING: 9606.ENSP00000334458

    UniGene: Hs.243987