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GAS7 Antibody

  • 货号：
    CSB-PA554215
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA554215(GAS7 Antibody) at dilution 1/50. (Original magnification: ×200)
    • The image is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA554215(GAS7 Antibody) at dilution 1/50. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: CSB-PA554215(GAS7 Antibody) at dilution 1/625, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    O60861
  • 基因名：
    GAS7
  • 别名：
    GAS 7 antibody; GAS-7 antibody; Gas7 antibody; GAS7_HUMAN antibody; Growth arrest specific 7 antibody; Growth Arrest Specific Protein 7 antibody; Growth arrest-specific protein 7 antibody; KIAA0394 antibody; MGC1348 antibody; MLL/GAS7 antibody; MLL/GAS7 fusion protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human GAS7
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
  • 基因功能参考文献：
    1. Polymorphism rs11656696 is not associated with primary open angle glaucoma (POAG) nor any of its endophenotypic traits such as intraocular pressure and cup/disk ratio and is thus not a risk factor for POAG in this Saudi cohort PMID: 29022762
    2. Collectively, our findings provide a novel basis for using miR-181a/GAS7-based therapeutic strategies to reverse gefitinib resistance in NSCLC. PMID: 29269300
    3. Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected PMID: 29261660
    4. These results demonstrate GAS7 as a susceptibility gene for schizophrenia. PMID: 27189492
    5. Low GAS7C increases cancer cell motility by promoting N-WASP/FAK/F-actin cytoskeleton dynamics. It also enhances beta-catenin stability via hnRNP U/beta-TrCP complex formation. PMID: 26506240
    6. We conclude that lower neuronal Gas7b levels may impact Alzheimer disease progression. PMID: 24151073
    7. The results suggest that regulation to maintain an appropriate concentration of hGas7b is required for healthy neurotransmission. PMID: 22496485
    8. These findings indicate that Gas7 is involved in motor neuron function associated with muscle strength maintenance. PMID: 22662195
    9. Intraocular pressure (IOP)was significantly associated with rs11656696, located in GAS7 at 17p13.1 and with rs7555523, located in TMCO1 at 1q24.1.These data suggest that we have identified two clinically relevant genes involved in IOP regulation. PMID: 22570627
    10. regulates the differentiation of mesenchymal stem cells into osteoblasts by enhancing Runx2-dependent gene expression PMID: 21452305
    11. Knockdown of Gas7 by shRNA preferentially suppressed the Gas7b protein isoform in human preneuronal cells and to reduce apoptosis induced either by serum starvation or by the antineoplastic agents in human neuroblastoma SH-SY5Y cells. PMID: 20890993
    12. This work reports the identification of two human Gas7 cDNA: hGas7-a with 2,427 nucleotides, which encodes 330 amino acids, and hGas7-b with 2,610 nucleotides, which encodes 412 amino acids according to predicted open-reading-frames. PMID: 15948147
    13. hGas7b has a role in microtubular maintenance and is possibly implicated in Alzheimer disease PMID: 19801671

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  • 相关疾病：
    A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.
  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    HGNC: 4169

    OMIM: 603127

    KEGG: hsa:8522

    STRING: 9606.ENSP00000407552

    UniGene: Hs.462214