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GAR1 Antibody

  • 中文名称：
    GAR1兔多克隆抗体
  • 货号：
    CSB-PA009257GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NY12
  • 基因名：
    GAR1
  • 别名：
    Gar1 antibody; GAR1_HUMAN antibody; H/ACA ribonucleoprotein complex subunit 1 antibody; nucleolar protein family A member 1 (H/ACA small nucleolar RNPs) antibody; Nucleolar protein family A member 1 antibody; snoRNP protein GAR1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GAR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 基因功能参考文献：
    1. The deregulated expression and function of H/ACA snoRNPs may underlie specific pathological features of human disease. PMID: 23707062
    2. The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. PMID: 19917616
    3. heterozygous point mutations in NOLA1 gene are not responsible for aplastic anemia in our patients at least acting via telomere PMID: 18989882
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
  • 蛋白家族：
    GAR1 family
  • 数据库链接：

    HGNC: 14264

    OMIM: 606468

    KEGG: hsa:54433

    STRING: 9606.ENSP00000226796

    UniGene: Hs.69851