GALT Antibody
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货号:CSB-PA009226LA01HU
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规格:¥440
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促销:
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图片:
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Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA009226LA01HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA009226LA01HU at dilution of 1:100
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Western Blot
Positive WB detected in: Rat liver tissue, Mouse kidney tissue
All lanes: GALT antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44, 32 kDa
Observed band size: 44 kDa -
Immunofluorescent analysis of Hela cells using CSB-PA009226LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Immunoprecipitating GALT in HepG2 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA009226LA01HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA009226LA01HU (8µg) + HepG2 whole cell lysate (500µg)
Lane 3: HepG2 whole cell lysate (10µg)
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其他:
产品详情
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产品描述:
The GALT polyclonal antibody was produced in three stages: first, a rabbit was immunized with the recombinant human Galactose-1-phosphate uridylyltransferase protein (1-379aa); then, antibodies were collected and isolated from the rabbit serum; and finally, the resulting antibodies were purified via protein G affinity chromatography.
This GALT polyclonal antibody contains few impurities, with a purity of over 95%. It is capable of detecting and binding to GALT protein from human, mouse, and rat samples. Its versatility has been demonstrated through successful implementation in various applications, including ELISA, WB, IHC, IF, and IP, indicating its effectiveness in diverse experimental contexts.
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产品名称:Rabbit anti-Homo sapiens (Human) GALT Polyclonal antibody
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Uniprot No.:P07902
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基因名:GALT
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别名:Gal 1 P uridylyltransferase antibody; Gal-1-P uridylyltransferase antibody; Galactose 1 phosphate uridyl transferase antibody; Galactose 1 phosphate uridylyltransferase antibody; Galactose-1-phosphate uridylyltransferase antibody; GALT antibody; GALT_HUMAN antibody; UDP glucose hexose 1 phosphate uridylyltransferase antibody; UDP-glucose--hexose-1-phosphate uridylyltransferase antibody
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宿主:Rabbit
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反应种属:Human, Mouse, Rat
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免疫原:Recombinant Human Galactose-1-phosphate uridylyltransferase protein (1-379AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,GALT Antibody (CSB-PA009226LA01HU),的标记方式是Non-conjugated。对于GALT Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC, IF, IP
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 IF 1:50-1:200 IP 1:200-1:2000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Plays an important role in galactose metabolism.
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基因功能参考文献:
- GALT mutation is associated with galactosemia. PMID: 29252199
- The mutational spectrum of the GALT gene in Greek galactosemia patients is presented for the first time. PMID: 28644047
- novel splicing mutation in GALT gene causing Galactosemia in Ecuadorian family PMID: 28450132
- 17 VUS (37%; 7 in ACADM, 9 in GALT, and 1 in PAH) were reclassified from uncertain (6 to benign or likely benign and 11 to pathogenic or likely pathogenic). We identified common types of missing information that would have helped make a definitive classification and categorized this information by ease and cost to obtain PMID: 27308838
- we present the 1.9 A resolution crystal structure of human GALT (hGALT) ternary complex, revealing a homodimer arrangement that contains a covalent uridylylated intermediate and glucose-1-phosphate in the active site, as well as a structural zinc-binding site, per monomer PMID: 27005423
- A novel noncoding homozygous GALT variant associated with asymptomatic galactosemia has been described in an infant of consanguineous heterozygous parents. PMID: 25920691
- Mutation activates a cryptic donor splice site, inducing an aberrant splicing of the GALT pre-mRNA, which in turn leads to a frameshift with inclusion of a premature stop codon. PMID: 25052314
- GALT activity in red blood cells of patients with galactosaemia PMID: 25268296
- Novel missense mutations identified in Italian galactosemic patients. PMID: 25592817
- In Korean population, novel GALT mutations were identified in the galactosemia patients different from those of other populations. PMID: 25124065
- suggests that GALT mutations are ethnic-specific and that galactosemia is a heterogeneous disorder at the molecular level PMID: 24045215
- In this report, we present GALT gene mutations in 56 cases of galactosemia from Turkey identified using DNA microarray resequencing. PMID: 23924834
- Data suggest that in classic galactosemia residual GALT activity (predicted from activity of recombinant GALT matching patient's mutation) correlates with reduced ovarian reserve (as indicted by biological marker, circulating anti-Mullerian hormone). PMID: 23690308
- HGALT requires a level of flexibility to function optimally and that altered folding is the underlying reason of impairment in all the variants tested here. PMID: 23583749
- The study determined the frequency of the two most common GALT mutations and their variants in Indian galactosemia patients. PMID: 22798028
- The novel GALT gene mutations included 6 missense mutations viz. Y89H, Q103R, P166A, S181F, K285R, R333L; one nonsense mutation, S307X and 3 silent mutations--Q103Q, K210K and H319H. PMID: 23022339
- Forty four novel variations in the GALT gene were identified, among them 27 nucleotide substitutions, in the French cohort of galactosemic patients. PMID: 22944367
- Mutations of the galactose-1-phosphate uridyltranseferase gene is associated with galactosemia. PMID: 22963887
- Duarte1 (D1) and D2 genotypes of GALT do not appear to play a role in the association between galactose intake, possible ovarian dysfunction, and the link with ovarian cancer PMID: 22749219
- 3 different GALT mutations viz. Q188R, N314D and S307X were found to be present in the family of a neonate diagnosed with galactosemia and having the heterozygote genotype Q188R/S307X. S307X is a novel GALT mutation linked to galactosemia. PMID: 21188552
- Results suggest that classical galactosaemia shows low allelic heterogeneity in Mexican patients. PMID: 18956253
- Congenital eye abnormalities and galactosemia were found in a family with Q188R and G1391A mutations. PMID: 20222886
- GALT deletion mutation carrier frequency was 1 in 127 (0.79%). PMID: 21059483
- live birth incidence of classical galactosemia in Estonia is 1:19.700 PMID: 20151200
- The simulated point mutations have a direct effect on the active site, or on the dimer assembly and stability, or on the monomer stability. PMID: 20008339
- no effect seen of N314D GALT genotype on risk of borderline or invasive ovarian cancer PMID: 11936817
- Data found no association between congenital absence of the uterus and vagina (CAUV) and the N314D allele of the galactose-1-phosphate uridyl transferase (GALT) gene. PMID: 12606594
- Increased expression of Galactosyltransferase is associated with ovarian cancer PMID: 12851678
- association of decreased galactose-1-phosphate uridyltransferase activity with idiopathic presenile cataract PMID: 14707519
- children and adolescents with galactosemia function generally within the low average IQ range and have less well-developed executive functions. PMID: 15506833
- No statistically significant differences were observed in the allele frequencies between the infertile women and control groups for GALT PMID: 15749517
- Nine novel mutations in the GALT gene associated with Classical galctosemia are described. PMID: 15841485
- No association of GALT mutations is found in 86 patients with idiopathic premature ovarian failure. PMID: 16009197
- We postulate that molecular link between defective GALT enzyme, which result in classic galactosemia and the cerebroside galactosyl transferase, responsible for galactosylation of cerebrosides, is dependent on concentrations of UDP-galactose. PMID: 16125333
- no relationship was found between ovarian failure and GALT polymorphisms in Indian women PMID: 16274605
- no significant differences between women carrying at least one N314D or Q188R GALT allele and controls in IVF outcomes measured: numbers of follicles and oocytes obtained; fertilization rates and percentage of Grade A embryos; and pregnancy rates. PMID: 16595241
- analysis of classical galactosaemia mutations in GALT1 in Spain and Portugal PMID: 17041746
- analysis of a patient with galactose-1-phosphate uridyltransferase mutations p.Q188R and p.R333W and galactose metabolite levels during breast-feeding [case report] PMID: 17143577
- Identified novel mutations in GALT gene using DNA testing. PMID: 17876724
- The R204X mutation severely compromises both expression and function of human GALT;T268N is one of a very small number of naturally occurring rare but neutral missense polymorphisms in human GALT. PMID: 18210213
- Synergistic effect of GALT and lactase mutations on cataract formation. PMID: 18454942
- 4 bp 5' deletion in GALT is a causal mutation in Duarte galactosemia. PMID: 19224951
- Galactose-1-phosphate uridyl transferase deficiency is not associated with Mullerian aplasia in Dutch patients PMID: 19646668
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相关疾病:Galactosemia (GALCT)
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蛋白家族:Galactose-1-phosphate uridylyltransferase type 1 family
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数据库链接:
HGNC: 4135
OMIM: 230400
KEGG: hsa:2592
STRING: 9606.ENSP00000368119
UniGene: Hs.522090
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