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GALNT11 Antibody

  • 中文名称：
    GALNT11兔多克隆抗体
  • 货号：
    CSB-PA847687LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA847687LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA847687LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA847687LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GALNT11 Polyclonal antibody
  • Uniprot No.：
    Q8NCW6
  • 基因名：
    GALNT11
  • 别名：
    A430075I06Rik antibody; AI648252 antibody; E430002F06Rik antibody; FLJ21634 antibody; GalNAc Transferase 11 antibody; GalNAc-T11 antibody; GalNAcT11 antibody; GALNT11 antibody; GLT11_HUMAN antibody; MGC71630 antibody; Polypeptide GalNAc transferase 11 antibody; Polypeptide N-acetylgalactosaminyltransferase 11 antibody; pp-GaNTase 11 antibody; Protein-UDP acetylgalactosaminyltransferase 11 antibody; tcag7.1057 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11 antibody; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 11 protein (420-606AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GALNT11 Antibody (CSB-PA847687LA01HU)，的标记方式是Non-conjugated。对于GALNT11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA847687LB01HU GALNT11 Antibody, HRP conjugated ELISA
    FITC CSB-PA847687LC01HU GALNT11 Antibody, FITC conjugated
    Biotin CSB-PA847687LD01HU GALNT11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).
  • 基因功能参考文献：
    1. possible role in the deterioration of kidney function [meta-analysis] PMID: 25493955
    2. evidence suggests that CLL patient samples harbor aberrant O-glycosylation highlighted by Tn antigen expression and that the over-expression of GALNT11 constitutes a new molecular marker for CLL PMID: 24076351
    3. GALNT11, the human ortholog to Drosophila melanogaster pgant35A, was shown not to support rescue of the l(2)35Aa lethality during Drosophila embryogenesis. PMID: 20422447
    4. Single nucleiotide polymorphism in the GALNT11 genes were investigated to assess allele frequencies in different populations. This SNP would be useful marker for forensic individualization, in particular, as ancestry-informative markers. PMID: 20547088
  • 相关疾病：
    Defects in GALNT11 may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family, GalNAc-T subfamily
  • 组织特异性：
    Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli.
  • 数据库链接：

    HGNC: 19875

    OMIM: 615130

    KEGG: hsa:63917

    STRING: 9606.ENSP00000315835

    UniGene: Hs.647109