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Fcmr Antibody

  • 货号：
    CSB-PA007972LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Fcmr antibody at 2µg/ml
      Lane 1: Rat spleen tissue
      Lane 2: Rat kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 48 kDa
      Observed band size: 48 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Fcmr Polyclonal antibody
  • Uniprot No.：
    A1KXC4
  • 基因名：
    Fcmr
  • 别名：
    Fcmr antibody; Faim3 antibody; TosoFas apoptotic inhibitory molecule 3 antibody; IgM Fc fragment receptor antibody; Regulator of Fas-induced apoptosis Toso antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Rat
  • 免疫原：
    Recombinant Mouse Fas apoptotic inhibitory molecule 3 protein (18-262AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Fcmr Antibody (CSB-PA007972LA01MO)，的标记方式是Non-conjugated。对于Fcmr Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007972LB01MO Fcmr Antibody, HRP conjugated ELISA
    FITC CSB-PA007972LC01MO Fcmr Antibody, FITC conjugated
    Biotin CSB-PA007972LD01MO Fcmr Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • 基因功能参考文献：
    1. Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection. PMID: 25257173
    2. these findings suggest that FcmuR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Fas (lpr/lpr) mice. PMID: 24994818
    3. FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge. PMID: 23267023
    4. Toso is a unique regulator of inflammatory autoimmune responses with a protective role against experimental autoimmune encephalomyelitis PMID: 24398517
    5. Toso is a unique regulator of innate immune responses during bacterial infection and septic shock. PMID: 23359703
    6. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
    7. mTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas ligand-induced apoptosis. PMID: 15632112

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 数据库链接：

    KEGG: mmu:69169

    STRING: 10090.ENSMUSP00000048303

    UniGene: Mm.46042