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  4. FUT8 Antibody

FUT8 Antibody

  • 货号：
    CSB-PA557036
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA557036(FUT8 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA557036(FUT8 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LoVo cells, PC3 cells, Primary antibody: CSB-PA557036(FUT8 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9BYC5
  • 基因名：
    FUT8
  • 别名：
    6-fucosyltransferase antibody; Alpha (1,6) fucosyltransferase antibody; Alpha-(1,6)-fucosyltransferase antibody; Alpha1 6FucT antibody; alpha1-6FucT antibody; Fucosyltransferase 8 (alpha (1,6) fucosyltransferase) antibody; Fucosyltransferase 8 antibody; FUT8 antibody; FUT8_HUMAN antibody; GDP fucose glycoprotein fucosyltransferase antibody; GDP L Fuc:N acetyl beta D glucosaminide alpha1,6 fucosyltransferase antibody; GDP-fucose--glycoprotein fucosyltransferase antibody; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1 antibody; Glycoprotein 6 alpha L fucosyltransferase antibody; Glycoprotein 6-alpha-L-fucosyltransferase antibody; MGC26465 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human FUT8
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
  • 基因功能参考文献：
    1. loss of function mutations in FUT8 cause a congenital disorder of glycosylation (FUT8-CDG) characterized by defective core fucosylation. PMID: 29304374
    2. we also demonstrated that overexpression of FUT8 might be responsible for the decreased PSA expression in prostate cancer specimens. To our knowledge, this is the first study reporting the functional role of fucosylated enzyme in the development of castration-resistant prostate cancer. PMID: 29339807
    3. This study thus provides insights into the interplay among FUT8, N-acetylglucosaminyltransferase , and GnT-V in N-linked glycosylation during the assembly of glycoproteins. PMID: 28678517
    4. Our results reveal a positive feedback mechanism of FUT8-mediated receptor core fucosylation that promotes TGF-b signaling and EMT, thus stimulating breast cancer cell invasion and metastasis. PMID: 28982386
    5. FUT8 is regulated by microRNAs and has a role in hepatocellular carcinoma progression PMID: 27533464
    6. We observed a strong correlation between EVI1 and alpha1, 6-fucosyltransferase (FUT8) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease. PMID: 27967290
    7. This study demonstrated that the alteration of FTU8 expression in the superior temporal gyrus of elderly patients with schizophrenia. PMID: 27773385
    8. results suggest that an appropriate polypeptide context or other adequate structural elements in the acceptor substrate could facilitate the core fucosylation by FUT8 PMID: 28729420
    9. FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination. PMID: 28609658
    10. The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO in the FUT8-overexpressed HEK293S GnT I(-/-) cell line represents the first example of production of fully core-fucosylated high-mannose glycoforms. PMID: 27008861
    11. Expression of FUT8 can stratify breast cancer tissue and may be considered a prognostic marker for breast cancer patients PMID: 26596733
    12. MiR-198 was shown to target the 3'UTR of FUT8 directly to downregulate FUT8 expression. PMID: 25174450
    13. High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor. PMID: 25572677
    14. Our results suggest that FUT8 may be associated with aggressive PCa and thus is potentially useful for its prognosis. PMID: 24906821
    15. miR-122 and miR-34a are able to target FUT8 3'UTR PMID: 24130780
    16. alpha 1,6-fucosyltransferase 8 expression might be a good indicator of poor prognosis in hepatocellular carcinoma. High alpha 1,6-fucosyltransferase 8 expression may play an important role in hepatitis B virus-related hepatocellular carcinoma progression PMID: 23352314
    17. findings define FUT8 as a novel factor for hemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation PMID: 23609441
    18. The FUT8 gene Thr267Lys polymorphism is associated with human pulmonary emphysema (PE). PMID: 22011814
    19. in colorectal carcinoma patients with moderate or strong alpha(1,6)fucosyltransferase expression, a significant decrease in the overall (P = .04) and disease-free (P = .03) survival rates was observed PMID: 21652057
    20. Expression of FUT8 is regulated by three different promoters, starting transcription in exons A, B, or C. PMID: 14514715
    21. These results suggest that FUT8 expression may be a key factor in the progression of thyroid papillary carcinomas, but not follicular carcinomas, and decreases in FUT8 expression might be linked to anaplastic transformation. PMID: 14568171
    22. We investigated mRNA levels of glycosyltransferases, namely N-acetylglucosaminyltransferase a (GnT)-IVb, and found that (GnT)-IVb expression was increased in HLE-cells resistant to Epirubicin PMID: 17488527
    23. Vascular endothelial growth factor receptor-2 (VEGFR-2) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 expression. PMID: 19179362

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 23 family
  • 数据库链接：

    HGNC: 4019

    OMIM: 602589

    KEGG: hsa:2530

    STRING: 9606.ENSP00000353910

    UniGene: Hs.597649