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FSCN2 Antibody

  • 货号：
    CSB-PA009011LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FSCN2 Polyclonal antibody
  • Uniprot No.：
    O14926
  • 基因名：
    FSCN2
  • 别名：
    Fascin homolog 2; actin bundling protein; retinal Strongylocentrotus purpuratus antibody; Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein; retinal antibody; Fascin-2 antibody; FSCN2 antibody; FSCN2_HUMAN antibody; Retinal fascin antibody; RFSN antibody; RP30 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Fascin-2 protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FSCN2 Antibody (CSB-PA009011LA01HU)，的标记方式是Non-conjugated。对于FSCN2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009011LB01HU FSCN2 Antibody, HRP conjugated ELISA
    FITC CSB-PA009011LC01HU FSCN2 Antibody, FITC conjugated
    Biotin CSB-PA009011LD01HU FSCN2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
  • 基因功能参考文献：
    1. diffuse expression in 82% of undifferentiated/dedifferentiated endometrial carcinomas PMID: 28272224
    2. Tax-mediated transcriptional induction of Fascin requires NF-kappaB- and TRR-dependent promoter activation, and a promoter-independent, but PP2-sensitive signaling pathway. PMID: 26363219
    3. the serum fascin level is an effective indicator of tumor aggressiveness, and that it plays an important role in the prognosis of NSCLC, particularly for non-distant metastatic patients. PMID: 24070574
    4. Data indicate the specific contribution of fascin and cortactin during invadopodium formation. PMID: 24414419
    5. The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin PMID: 21975552
    6. Fascin expression predicts survival after potentially curative resection of node-positive colon cancer. PMID: 20410808
    7. The 208delG mutation in the FSCN2 gene produces not only autosomal dominant retinitis pigmentosa but also ADMD (autosomal dominant macular degeneration) PMID: 14609921
    8. The photoreceptor-specific FSCN2 gene showed a relatively high number of sequence variations. PMID: 16280978
    9. The 208delG mutation in FSCN2 is not associated with hereditary retinal degeneration in the Chinese individuals examined. PMID: 17251446
    10. Real-time PCR-based genotyping method developed here is useful for investigations of allelic asymmetries within genomic regions with variations found in retinitis pigmentosa and retinl degeneration. PMID: 18450588
    11. In ovarian tumors fascin is associated with certain features of increased tumor aggressiveness. PMID: 18498068
    12. Higher fascin scores correlated positively with tumor differentiation of esophageal SqCC. Significantly worse prognosis in patients with high scores of fascin, poor differentiation, T4 stage, positive for lymph node metastasis and distant metastasis PMID: 19207554
    13. expression may play an essential role in regulation of progression of oral squamous cell carcinoma and contributes to the event of epithelial-mesenchymal transition in the early aggressiveness of OSCC PMID: 19473443

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  • 相关疾病：
    Retinitis pigmentosa 30 (RP30)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, stereocilium.
  • 蛋白家族：
    Fascin family
  • 组织特异性：
    Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.
  • 数据库链接：

    HGNC: 3960

    OMIM: 607643

    KEGG: hsa:25794

    STRING: 9606.ENSP00000334665

    UniGene: Hs.118555