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FRMD5 Antibody

  • 货号：
    CSB-PA773602LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FRMD5 antibody at 16 μg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: Mouse heart tissue
      Lane 3: Mouse skeletal muscle tissue
      Lane 4: Mouse lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 66, 64 kDa
      Observed band size: 65 kDa
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA773602LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA773602LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA773602LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FRMD5 Polyclonal antibody
  • Uniprot No.：
    Q7Z6J6
  • 基因名：
    FRMD5
  • 别名：
    FRMD5; FERM domain-containing protein 5
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human FERM domain-containing protein 5 protein (295-504AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FRMD5 Antibody (CSB-PA773602LA01HU)，的标记方式是Non-conjugated。对于FRMD5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA773602LB01HU FRMD5 Antibody, HRP conjugated ELISA
    FITC CSB-PA773602LC01HU FRMD5 Antibody, FITC conjugated
    Biotin CSB-PA773602LD01HU FRMD5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation.
  • 基因功能参考文献：
    1. We conclude that integrative variants, haplotypes and diplotypes of the CAPN3 rs4344713 and FRMD5 rs524908, as well as DBP and BMI are associated with serum lipid variables in the Jing and Han populations. PMID: 28332615
    2. Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells. PMID: 28117551
    3. FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 PMID: 25448675
    4. FRMD5 may play a role in p120-catenin-based cell-cell contact and is involved in the regulation of tumor progression PMID: 22846708
  • 亚细胞定位：
    Membrane; Single-pass membrane protein. Cell junction, adherens junction.
  • 数据库链接：

    HGNC: 28214

    OMIM: 616309

    KEGG: hsa:84978

    STRING: 9606.ENSP00000403067

    UniGene: Hs.578544