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FOXRED1 Antibody

  • 货号：
    CSB-PA822192ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FOXRED1 antibody at 5.28µg/ml + A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 54, 31, 53 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822192ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA822192ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FOXRED1 Polyclonal antibody
  • Uniprot No.：
    Q96CU9
  • 基因名：
    FOXRED1
  • 别名：
    FOXRED1; FP634; FAD-dependent oxidoreductase domain-containing protein 1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human FAD-dependent oxidoreductase domain-containing protein 1 protein (307-486AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
  • 基因功能参考文献：
    1. Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I. PMID: 27215383
    2. Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I. PMID: 26235939
    3. A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site. PMID: 25765152
    4. FOXRED1 is a crucial component in the productive assembly of respiratory chain complex I and that mutations in FOXRED1 leading to partial loss of function cause defects in complex I biogenesis. PMID: 25678554
    5. Mutations in FOXRED1 are associated with complex I deficiency. PMID: 20818383

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  • 相关疾病：
    Mitochondrial complex I deficiency (MT-C1D)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 数据库链接：

    HGNC: 26927

    OMIM: 252010

    KEGG: hsa:55572

    STRING: 9606.ENSP00000263578

    UniGene: Hs.317190