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FOXH1 Antibody

  • 货号：
    CSB-PA002487
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using FAST-1/2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O75593
  • 基因名：
    FOXH1
  • 别名：
    FAST 1 antibody; Fast 2 antibody; Fast-1 antibody; Fast-2 antibody; FAST1 antibody; Fast2 antibody; Forkhead activin signal transducer 1 antibody; Forkhead activin signal transducer 2 antibody; Forkhead box H1 antibody; Forkhead box protein H1 antibody; FOX H1 antibody; FOXH 1 antibody; FOXH1 antibody; FOXH1_HUMAN antibody; hFAST 1 antibody; hFAST-1 antibody; hFAST1 antibody; Human homolog of Xenopus forkhead activin signal transducer 1 antibody; TGF beta/Activin signal transducer FAST1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human FAST-1/2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
  • 基因功能参考文献：
    1. These results indicate that Smad4 acts as a tumor suppressor by activating FOXH1, and then suppressing the expression of estrogen receptor, in addition to tumor migration and invasion. PMID: 25482028
    2. HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1 PMID: 21828274
    3. Four genetic variants are found in FOXH1 that are associated with ventricular septal defects in Chinese patients. PMID: 19525021
    4. Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1. PMID: 19711044
    5. This work suggests that FAST-1 may participate in the vascular smooth muscle response to injury and may represent a potential molecular target for modulating the progression of cardiac allograft vasculopathy. PMID: 15737749
    6. Smad-binding peptide aptamer FOXH1 can be developed to selectively inhibit TGF-beta-induced gene expression. PMID: 15750622
    7. These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis. PMID: 15982639
    8. FoxH1 has a role in androgen receptor-mediated transactivation PMID: 16120611
    9. Reduced NODAL signaling via mutation of several pathway members including FOXH1 is linked to heart defects and holoprosencephaly. PMID: 18538293

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 3814

    OMIM: 603621

    KEGG: hsa:8928

    STRING: 9606.ENSP00000366534

    UniGene: Hs.708365