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FN3K Antibody

  • 货号：
    CSB-PA008760GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H479
  • 基因名：
    FN3K
  • 别名：
    FN3KFructosamine-3-kinase antibody; EC 2.7.1.171 antibody; Protein-psicosamine 3-kinase FN3K antibody; Protein-ribulosamine 3-kinase FN3K antibody; EC 2.7.1.172 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human FN3K
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines.
  • 基因功能参考文献：
    1. In a multiple regression analysis, FN3K rs1056534, TF polymorphism and presence of diabetes mellitus were predictors for HHV-8 infection. PMID: 27461879
    2. FN3K could act in concert with other molecular mechanisms and may impact on gene expression and activity of other enzymes involved in deglycation process PMID: 26352355
    3. Report association of rs1056534 and rs3848403 of fructosamine 3-kinase gene with sRAGE in patients with diabetes. PMID: 24908234
    4. The marginal association of rs1056534 of FN3K is located in exon 6 with diabetic nephropathy progression. PMID: 23492569
    5. two new mutations and additional variants within the FN3K gene in diabetic patients PMID: 21288167
    6. These findings suggest that deglycating enzymes Glyoxalase I and fructosamine-3-kinase may be involved in the malignant transformation of colon mucosa. PMID: 21253391
    7. G900C polymorphism associates with the level of HbA (1c) and the onset of type 2 diabetes mellitus, but not with either of the diabetic microvascular complications. PMID: 19834870
    8. involved in the removal of fructosamine residues from hemoglobin in erythrocytes. PMID: 11975663
    9. The aim of this work was to identify the fructosamine residues on hemoglobin that are removed as a result of the action of FN3K in intact erythrocytes. PMID: 15102834
    10. These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state. PMID: 15381090
    11. Enzyme is a constitutive "housekeeping" gene and that ig plays an important role in cell metabolism, possibly as a deglycating enzyme. PMID: 16037310
    12. No significant correlation between FN3K activity and the levels of HbA1c, total glycated haemoglobin (GHb) and haemoglobin fructoselysine residues, either in the normoglycaemic or diabetic group. PMID: 16523184
    13. In this paper we propose a resolution of both these quandaries by proposing that fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by FN3KRP and/or possibly FN3K. PMID: 16920277

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  • 蛋白家族：
    Fructosamine kinase family
  • 组织特异性：
    Widely expressed. Expressed in erythrocytes.
  • 数据库链接：

    HGNC: 24822

    OMIM: 608425

    KEGG: hsa:64122

    STRING: 9606.ENSP00000300784

    UniGene: Hs.151135