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FMNL3 Antibody

  • 货号：
    CSB-PA815554LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA815554LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA815554LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA815554LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FMNL3 Polyclonal antibody
  • Uniprot No.：
    Q8IVF7
  • 基因名：
    FMNL3
  • 别名：
    FMNL3 antibody; FHOD3 antibody; FRL2 antibody; KIAA2014 antibody; WBP3 antibody; Formin-like protein 3 antibody; Formin homology 2 domain-containing protein 3 antibody; WW domain-binding protein 3 antibody; WBP-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Formin-like protein 3 protein (2-212AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FMNL3 Antibody (CSB-PA815554LA01HU)，的标记方式是Non-conjugated。对于FMNL3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA815554LB01HU FMNL3 Antibody, HRP conjugated ELISA
    FITC CSB-PA815554LC01HU FMNL3 Antibody, FITC conjugated
    Biotin CSB-PA815554LD01HU FMNL3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
  • 基因功能参考文献：
    1. Study revealed an essential role for FMNL3 in regulating the RhoC/FAK pathway and actin assembly dynamics, and the subsequent promotion of colorectal carcinoma invasion. PMID: 30228782
    2. FMNL3, the target gene of miR-127, is upregulated and acting as an oncogene in ESCC PMID: 27645894
    3. FMNL3 functions in assembly of actin-based protrusions that are specialized for cell-cell adhesion. PMID: 25428984
    4. FMNL3 plays an important role in the progression and metastasis of colorectal carcinoma and may be a novel potential prognostic predictor in colorectal carcinoma. PMID: 25758200
    5. Formin-like 3 (FMNL3) is a crucial regulator of endothelial cell elongation during angiogenesis. PMID: 22275430
    6. Protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3. PMID: 22790947
    7. Data suggest that the FH2 domain of FRL2 possesses properties not shared by FRL1 that allow it to generate filopodia. PMID: 20862687

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Lipid-anchor. Note=Enriched in lamellipodia.
  • 蛋白家族：
    Formin homology family
  • 组织特异性：
    Expressed in endothelial cells.
  • 数据库链接：

    HGNC: 23698

    OMIM: 616288

    KEGG: hsa:91010

    STRING: 9606.ENSP00000335655

    UniGene: Hs.179838