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FMNL1 Antibody

  • 货号：
    CSB-PA008743LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008743LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA008743LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FMNL1 Polyclonal antibody
  • Uniprot No.：
    O95466
  • 基因名：
    FMNL1
  • 别名：
    8030453N10Rik antibody; AI553564 antibody; C17orf1 antibody; C17orf1B antibody; CLL associated antigen KW 13 antibody; CLL-associated antigen KW-13 antibody; FHOD4 antibody; FMNL antibody; FMNL_HUMAN antibody; Fmnl1 antibody; Fnrl antibody; Formin like 1 antibody; Formin like antibody; Formin related protein antibody; Formin-like protein 1 antibody; Frls antibody; KW 13 antibody; KW13 antibody; Leukocyte formin antibody; MGC133052 antibody; MGC1894 antibody; MGC21878 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Formin-like protein 1 protein (207-457AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FMNL1 Antibody (CSB-PA008743LA01HU)，的标记方式是Non-conjugated。对于FMNL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008743LB01HU FMNL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA008743LC01HU FMNL1 Antibody, FITC conjugated
    Biotin CSB-PA008743LD01HU FMNL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
  • 基因功能参考文献：
    1. FMNL1 contributes to leukemogenesis and could act in part through Rac1 regulation. PMID: 23801653
    2. constitutively activated form of FMNL1 (FMNL1gamma) induces localization of AHNAK1 to the cell membrane. PMID: 23182705
    3. Results suggest that macrophage coiling phagocytosis is a complex process involving several actin nucleation/regulatory factors. They also point specifically to the formins mDia1 and FMNL1 as novel regulators of spirochete uptake by human immune cells. PMID: 23460512
    4. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics. PMID: 21148482
    5. Our data suggest that FRL1 is responsible for modifying actin at the macrophage podosome and may be involved in actin cytoskeleton dynamics during adhesion and migration within tissues. PMID: 20617518
    6. Results describe N-myristoylation as a regulative mechanism of FMNL1 responsible for membrane trafficking potentially involved in a diversity of polarized processes of hematopoietic lineage-derived cells. PMID: 19815554
    7. Western blot analysis demonstrated that the protein encoded by this gene is overexpressed in lymphoid malignancies, cancer cell lines and peripheral blood leukocyte from chronic lymphocytic leukemia (CLL) patients. PMID: 14592423

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome.; [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
  • 蛋白家族：
    Formin homology family
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 1212

    OMIM: 604656

    KEGG: hsa:752

    STRING: 9606.ENSP00000329219

    UniGene: Hs.100217