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FMN1 Antibody

  • 货号：
    CSB-PA715012LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, A549 whole cell lysate
      All lanes: FMN1 antibody at 3.9µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 158, 72, 54, 133 kDa
      Observed band size: 158 kDa
    • IHC image of CSB-PA715012LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA715012LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FMN1 Polyclonal antibody
  • Uniprot No.：
    Q68DA7
  • 基因名：
    FMN1
  • 别名：
    FMN1 antibody; FMN antibody; LDFormin-1 antibody; Limb deformity protein homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Formin-1 protein (354-487AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FMN1 Antibody (CSB-PA715012LA01HU)，的标记方式是Non-conjugated。对于FMN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA715012LB01HU FMN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA715012LC01HU FMN1 Antibody, FITC conjugated
    Biotin CSB-PA715012LD01HU FMN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the formation of adherens junction and the polymerization of linear actin cables.
  • 基因功能参考文献：
    1. Formin-1 (FMN1) was shown to reside in the nucleus and studies indicate that some formins can shuttle in and out of the nucleus. PMID: 27913680
    2. actin arcs populating the medial, lamella-like region of the immunological synapse (IS) arise from linear actin filaments generated by one or more formins present at the IS distal edge. PMID: 27799367
    3. Filopodia initiation: focus on the Arp2/3 complex and formins. PMID: 21975549
    4. Chromosomal imbalances in the GREM1 FMN1 region in individuals with limb defects are reported here. PMID: 20610440
    5. The obtained data indicate the possibility of participation of polymorphism in gene FMN1 in formation of predisposition to prostate cancer. PMID: 20540360
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20540360
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 20200978
    9. both mammalian Spir proteins, Spir-1 and Spir-2, interact with mammalian Fmn subgroup proteins formin-1 and formin-2 PMID: 19605360
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19096130

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Formin homology family, Cappuccino subfamily
  • 数据库链接：

    HGNC: 3768

    OMIM: 136535

    KEGG: hsa:342184

    STRING: 9606.ENSP00000333950

    UniGene: Hs.657649