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FLVCR2 Antibody

  • 货号：
    CSB-PA892364ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FLVCR2 antibody at 0.83µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Mouse lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58, 36 kDa
      Observed band size: 58 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892364ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FLVCR2 Polyclonal antibody
  • Uniprot No.：
    Q9UPI3
  • 基因名：
    FLVCR2
  • 别名：
    FLVCR2 antibody; C14orf58Feline leukemia virus subgroup C receptor-related protein 2 antibody; Calcium-chelate transporter antibody; CCT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Feline leukemia virus subgroup C receptor-related protein 2 protein (1-100AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.
  • 基因功能参考文献：
    1. Mutations in FLVCR2 associated with Fowler syndrome and survival beyond infancy PMID: 25677735
    2. Mutations in FLVCR2 gene are responsible for Proliferative vasculopathy and Hydranencephaly-hydrocephaly syndrome. FLVCR2 transporter is gatekeeper for the controlled entry of calcium into cell, and involves the regulation of calcium metabolism. PMID: 25906927
    3. FLVCR2 mutation is associated with Hydranencephaly. PMID: 25131804
    4. High-throughput sequence data identified mutations and a large deletion in the FLVCR2 gene casuing lethal cerebral vasculopathy. PMID: 20690116
    5. Results report the cellular function of FLVCR2 as an importer of heme. PMID: 20823265
    6. Direct sequencing of candidate genes within the target interval in chromosome 14q24.3 revealed five different germline mutations in FLVCR2 in five families with Fowler syndrome. PMID: 20206334

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  • 相关疾病：
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family
  • 组织特异性：
    Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver and kidney. Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow). Found in acidophil cells o
  • 数据库链接：

    HGNC: 20105

    OMIM: 225790

    KEGG: hsa:55640

    STRING: 9606.ENSP00000238667

    UniGene: Hs.509966