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FLOT2 Antibody

  • 货号：
    CSB-PA183922
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extract from JK, HUVEC, HepG2 and Hela cells using ESA(FLOT2) Antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FLOT2 Polyclonal antibody
  • Uniprot No.：
    Q14254
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence around aa.420~424(I-K-K-A-T) derived from Human ESA (FLOT2).
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
  • 基因功能参考文献：
    1. miR-133 involves in lung adenocarcinoma cell metastasis by targeting FLOT2 PMID: 28503944
    2. Results provide evidence that Flot2 plays an important role in the progression of nasopharyngeal carcinoma cells, which may be partially related to its interaction with PLCD3. PMID: 29115528
    3. Flot-2 protein expression was significantly elevated in cancerous tissues and Flot-2 played pivotal roles in the development and progression of cancers. Increased expression of Flot-2 was correlated to a poor prognosis in cancer patients. Review. PMID: 27981826
    4. Data indicate miR-802 as a tumor suppressor in prostate cancer (PCa) progression and elucidated a novel mechanism of the miR-802/Flotillin-2 (Flot2) axis in the regulation of epithelial-mesenchymal transition (EMT), which may be a potential therapeutic target. PMID: 28188157
    5. We demonstrated that LXR stimulation decreases mRNA and protein expression of FLOT2 and DHHC5 in MCF-7 cells. LXR stimulation also reduces Akt phosphorylation and its localization at the plasma membrane PMID: 28739689
    6. Ectopic Flot2 could significantly reverse miR-485-mediated inhibition of metastasis and EMT, demonstrating Flot2 downregulation is involved in function of miR-485 PMID: 27262438
    7. Western blot experiments designed to detect flotillin 2, TMEM256, Rab3B and LAMTOR1 showed that the level of these proteins was higher in urinary exosomes from prostate cancer patients compared to healthy males, and ELISA-based detection of flotillin 2 and PARK7 showed that the combination of these proteins was able to distinguish prostate cancer patients and healthy controls with 68% sensitivity and 93% specificity PMID: 27664330
    8. This study presents the endocytic pathways of internalization for muscarinic type 3 receptor and flotillin-1/2 in salivary gland epithelial cells. knockdown of flot-1 or -2 by flotillin-specific siRNA prevented internalization and reduced the endocytic efficiency of muscarinic type 3 receptor. PMID: 27221048
    9. There was a strong association between polymorphisms of flotillin-2 gene and CAD in the Chinese Han population PMID: 26556629
    10. Flot-2 exerts a pro-neoplastic role in NPC and is involved in tumor progression and metastasis. Moreover, Flot-2 exerts its role through NF-kappaB and PI3K/Akt3 signaling. PMID: 26206082
    11. Positive expression of Flot-2 protein may be an independent biomarker for poor prognosis in oral squamous cell carcinoma. PMID: 26339392
    12. Flot2 is an indispensable member for TGF-beta signaling, which is essential for the epithelial-mesenchymal transition process in nasopharyngeal carcinoma metastasis PMID: 25909165
    13. increased expression of Flot-2 and EGFR in non-small cell lung cancer patients is inversely proportional to the disease prognosis. PMID: 26161893
    14. that miR-449a suppressed Flot2 expression results in decreased cell invasion through repressing TGF-beta-mediated-epithelial-mesenchymal transition PMID: 26576674
    15. Knockdown of FLOT2 decreases breast cancer cell proliferation. Silencing of FLOT2 enhanced the transcriptional activity of FOXO factors by decreasing its phosphorylation through inhibiting the PI3K/Akt signaling pathway. PMID: 25738752
    16. Our findings provided that high FLOT2 expression was associated with poor outcomes in non-small cell lung cancer patients PMID: 25755751
    17. FLOT2 may serve as an oncogene in the development of cervical cancer PMID: 25755754
    18. Flotillin 2 (FLOT2) is a direct target of microRNA-34a and the miR-34a/FLOT2 pathway plays a key role in melanoma proliferation and metastasis. PMID: 25403318
    19. Flotillin-2 is plays a role in the initial steps of skeletal myogenesis. PMID: 25105415
    20. results suggest that the increased expression of Flot-2 protein is a novel higher sensitivity biomarker that can predict lymph node metastases in NPC. PMID: 25014228
    21. Our data suggest that FLOT2 is a novel molecule involved in renal cell carcinoma progression PMID: 25053596
    22. Study suggests the Flot2 protein expression is correlated with cancer progression and poor prognosis in gastric carcinomas, probably due to its role in the regulation of cell proliferation, migration, and invasion in gastric carcinoma cells. PMID: 24854103
    23. The FLOT2 is abundantly expressed in term villous placental CTs and endothelial cells, and in comparison, expression of these proteins in the ST is reduced. PMID: 23064789
    24. Depletion of either flotillin-1 or flotillin-2 resulted in downregulation of ErbB3 and a selective reduction of ErbB2-ErbB3 receptor complexes. PMID: 24747692
    25. Flotillins directly interact with gamma-catenin and regulate epithelial cell-cell adhesion. PMID: 24391950
    26. High FLOT2 protein expression was associated with poor outcomes in patients with breast cancer. PMID: 23945257
    27. We have identified flotillin 1 and 2 as new partners of the cadherin complexes PMID: 24046456
    28. Results identify reggie-1 as a regulator of the Rab11a/SNX4-controlled sorting and recycling pathway. PMID: 23825023
    29. By virtue of its abundant expression in enterocytes, flotillin-2 must have an essential function in intestinal physiology, especially in the colon. PMID: 23983584
    30. Flot2 is an important regulator of mammary tumor-derived lung metastasis PMID: 23146906
    31. a positive correlation exists between flotillin2 and erbB2 expression levels PMID: 23658725
    32. Report role for flotillin 1/2 in interactions of lung epithelial cells with silica nanoparticles. PMID: 22669515
    33. we describe how flotillin-1 and -2 contribute to the stabilization of ErbB2 at the cell surface in breast cancer tissue PMID: 22869152
    34. results support predominant formation of flotillin-1 and -2 hetero-oligomers in resting and chemokine-stimulated human T-cells which may importantly contribute to structuring of the uropod. PMID: 23012365
    35. by promoting EGFR internalization, reggie-1 restricts EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate adherens junction formation PMID: 22438585
    36. potentially relevant protein substrates of DHHC5 PMID: 22081607
    37. Reggie-1 (flotillin-2) dynamically colocalizes with KIF9 in living cells PMID: 21119006
    38. flotillins have a role in NPC1L1-mediated cholesterol uptake and NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption PMID: 21187433
    39. Studies indicate that spatial link between PrP and the microdomain-forming protein flotillins may contribute to PrP signaling, leading to thelocal assembly of membrane protein complexes at sites involved in cellular communication. PMID: 20515742
    40. In hematopoietic cells, flotillins provide intrinsic cues that govern segregation of certain microdomain-associated molecules during immune cell polarization. PMID: 20027317
    41. Flot-2 overexpression is associated with melanoma progression, with increased PAR-1 expression, and with transformation of SB2 melanoma cells to a highly metastatic line. PMID: 15492257
    42. flotillin-2 identified and immunolocalized in the caveola-vesicle complexes (CVC )present in erythrocytes infected with P. vivax PMID: 16521037
    43. flotillin-2 has a role in lymph node metastasis in melanoma PMID: 17013097
    44. The results showed that flotillin-1 can interact with arginase1, and hence arginase activity was up-regulated by 26.8%. PMID: 17113085
    45. These lines of evidence suggested that a Gq-coupled receptor activates specifically p38 MAPK through lipid rafts and Src kinase activation, in which flotillins positively modulate the Gq signaling. PMID: 17307333
    46. Coassembly of flotillin1 and flotillin2 into microdomains induces membrane curvature, the formation of plasma-membrane invaginations morphologically similar to caveolae, and the accumulation of intracellular vesicles. PMID: 17600709
    47. Reggie-1/flotillin-2 microdomains form independent of actin PMID: 17854803
    48. deletion mutants of reggie-1/flotillin-2 accumulate in the Golgi complex in HeLa and Jurkat cells, suggesting Golgi-dependent trafficking of reggie-1/flotillin-2 PMID: 18237819
    49. Flotillin 2 is a direct transcriptional target of the p53 family member genes in human cancer cells. PMID: 18296650
    50. The interaction of flotillin-2 with amyloid precursor protein (APP) promotes the clustering of APP at the cell surface. PMID: 18337418

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Membrane; Lipid-anchor. Note=Membrane-associated protein of caveolae.
  • 蛋白家族：
    Band 7/mec-2 family, Flotillin subfamily
  • 组织特异性：
    In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carci
  • 数据库链接：

    HGNC: 3758

    OMIM: 131560

    KEGG: hsa:2319

    STRING: 9606.ENSP00000378368

    UniGene: Hs.514038