FKBPL Antibody
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货号:CSB-PA904562
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规格:¥2024
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图片:
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) FKBPL Polyclonal antibody
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Uniprot No.:Q9UIM3
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基因名:FKBPL
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from internal of Human FKBPL.
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免疫原种属:Homo sapiens (Human)
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克隆类型:Polyclonal
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纯化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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浓度:It differs from different batches. Please contact us to confirm it.
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产品提供形式:Liquid
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应用范围:ELISA,WB
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:3000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.
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基因功能参考文献:
- This study identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 x 10-5) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 x 10-5) associated with breast cancer risk. PMID: 27479355
- The data suggests a role for FKBPL as a prognostic factor for BCSS, with the potential to be routinely evaluated within the clinic. PMID: 25906750
- WISp39 preferentially interacts with phosphorylated Coronin 1B, allowing it to complex with Slingshot phosphatase to dephosphorylate and activate Cofilin. PMID: 25800056
- FKBPL is an important regulator of developmental and pathological angiogenesis. PMID: 25767277
- high levels of FKBPL and RBCK1 correlated with increased patient survival, whereas high RBCK1 predicted for a poor response to tamoxifen. PMID: 23912458
- FKBPL and and its peptide derivative, AD-01 regulate expression of CD44. PMID: 23457460
- Genome-wide association study of age-related macular degeneration identifies TNXB, FKBPL and NOTCH4 as candidate susceptibility genes. PMID: 22694956
- Alterations in the gene for FKBPL in azoospermic patients. PMID: 20210997
- Findings suggest that FKBPL may have prognostic value based on its impact on tumor proliferative capacity and sensitivity to endocrine therapies, which improve outcome. PMID: 20103631
- Results demonstrate the importance of posttranslational stabilization of p21 protein by WISp39 in regulating cellular p21 activity. PMID: 15664193
- FKBPL can be classed as a new member of the FKBP protein family with a role in steroid receptor complexes and signaling. PMID: 18669603
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组织特异性:Ubiquitously expressed with higher levels in testis.
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数据库链接:
HGNC: 13949
KEGG: hsa:63943
STRING: 9606.ENSP00000364298
UniGene: Hs.520042
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