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FKBP1B Antibody

  • 货号：
    CSB-PA008692LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA008692LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FKBP1B Polyclonal antibody
  • Uniprot No.：
    P68106
  • 基因名：
    FKBP1B
  • 别名：
    Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12), FKBP1B, FKBP12.6 FKBP1L FKBP9 OTK4
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1B protein (1-108aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FKBP1B Antibody (CSB-PA008692LA01HU)，的标记方式是Non-conjugated。对于FKBP1B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008692LB01HU FKBP1B Antibody, HRP conjugated ELISA
    FITC CSB-PA008692LC01HU FKBP1B Antibody, FITC conjugated
    Biotin CSB-PA008692LD01HU FKBP1B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 基因功能参考文献：
    1. Our FRET-based HTS detects RyR binding of accessory proteins calmodulin (CaM) or FKBP12.6...One compound increased FRET and inhibited RyR1, which was only significant at nM [Ca(2+)], and accentuated without CaM present. PMID: 27760856
    2. Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 PMID: 27670942
    3. results suggest that both FKBP12.6 and FKBP12 play critical roles in regulating RyR2 function by facilitating the termination of SOICR. PMID: 27154203
    4. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium. PMID: 23887639
    5. FKBP12.6-deficient mice with cardiac hypertrophy do not display exercise-induced arrhythmia and/or sudden cardiac death. PMID: 22087651
    6. analysis of the ryanodine receptor FK506-binding protein subunit PMID: 20404344
    7. Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling. PMID: 20431056
    8. localization of binding site to the NH2-terminal domain of the cardiac Ca2+ release channel PMID: 12446682
    9. Data show that VTSIP- and ARVD2-associated point mutations influence positively and negatively, respectively, the binding of RyR2 to its gating protein FKBP12.6. PMID: 12459180
    10. data demonstrate that defective regulation of ryanodine receptor 2 causes altered cellular phenotype via profound perturbations in intracellular calcium signaling and highlight a key modulatory role of FK506 binding protein 12.6 PMID: 12754204
    11. FKBP1B gene is involved in the genetic susceptibility to the AITDs development in the studied family. PMID: 15497458
    12. novel interaction site for FKBP12.6 may be present at the RyR2 C terminus, proximal to the channel pore, a sterically appropriate location that would enable this protein to play a central role in the modulation of this critical ion channel PMID: 15591045
    13. FKBP12.6 plays a critical role in Ca channel gating, the R2401H mutation can be expected to alter Ca-induced Ca release and E-C coupling resulting in CPVT. PMID: 15749201
    14. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. PMID: 15972811
    15. the redox state of the RyR is intimately connected with FKBP binding affinity. PMID: 17200109
    16. Data show that K201 abolished spontaneous calcium release in cardiac myocytes, and that treating ventricular myocytes with FK506 to dissociate FKBP12.6 from ryanodine receptor RyR2 did not affect the suppression of spontaneous Ca2+ release by K201. PMID: 17313373
    17. Results describe abrupt changes in the expression of FKBP12.6, SERCA2a, PKA, and ECE on reperfusion against ischemia, which are responsible for the rapid occurrence of ventricular fibrillation, and their prevention by CPU86017. PMID: 17506935
    18. the loss of FKBP12.6 has no significant effect on the conduction and activation of RyR2 or the propensity for spontaneous Ca(2+) release and stress-induced ventricular arrhythmias PMID: 17921453
    19. The findings suggest that FKBP12.6 regulation of RyR2 is unlikely to be the primary defect in inherited arrhythmogenic cardiac disease. PMID: 19226252

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  • 亚细胞定位：
    Cytoplasm. Sarcoplasmic reticulum.
  • 蛋白家族：
    FKBP-type PPIase family, FKBP1 subfamily
  • 组织特异性：
    Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
  • 数据库链接：

    HGNC: 3712

    OMIM: 600620

    KEGG: hsa:2281

    STRING: 9606.ENSP00000370373

    UniGene: Hs.709461