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  4. FIGNL1 Antibody

FIGNL1 Antibody

  • 中文名称：
    FIGNL1兔多克隆抗体
  • 货号：
    CSB-PA008677GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6PIW4
  • 基因名：
    FIGNL1
  • 别名：
    FIGNL1Fidgetin-like protein 1 antibody; EC 3.6.4.- antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human FIGNL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic.
  • 基因功能参考文献：
    1. FIGL-1 is a new centrosomal protein and inhibits ciliogenesis. PMID: 27384458
    2. Further research assessing the functions and mechanisms of FIGNL1, and other homologous recombination pathway genes may disclose unique pathological characteristics of SCLC, and help identify potential therapeutic targets and biomarkers PMID: 28260065
    3. RAD51-binding protein fidgetin-like 1 (FIGNL1) is identified; FIGNL1 specifically interacts with RAD51 through its conserved RAD51 binding domain. Cells depleted of FIGNL1 show defective homologous recombination repair. PMID: 23754376
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment (PubMed:23754376).
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 13286

    OMIM: 615383

    KEGG: hsa:63979

    STRING: 9606.ENSP00000349356

    UniGene: Hs.137516