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FHOD1 Antibody

  • 货号：
    CSB-PA896540LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA896540LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FHOD1 Polyclonal antibody
  • Uniprot No.：
    Q9Y613
  • 基因名：
    FHOD1
  • 别名：
    FH1/FH2 domain containing protein antibody; FH1/FH2 domain containing protein 1 antibody; FH1/FH2 domain-containing protein 1 antibody; Fhod1 antibody; FHOD1_HUMAN antibody; FHOS antibody; FHOS1 antibody; Formin homolog overexpressed in spleen 1 antibody; Formin homology 2 domain containing 1 antibody; Formin homology 2 domain containing protein 1 antibody; Formin homology 2 domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human FH1/FH2 domain-containing protein 1 protein (338-437AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FHOD1 Antibody (CSB-PA896540LA01HU)，的标记方式是Non-conjugated。对于FHOD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896540LB01HU FHOD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA896540LC01HU FHOD1 Antibody, FITC conjugated
    Biotin CSB-PA896540LD01HU FHOD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.
  • 基因功能参考文献：
    1. results suggest that FHOD1 participates in key cellular processes that are dysregulated in malignancy PMID: 27919746
    2. FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes. PMID: 26621033
    3. Immunostaining of sections of hearts with both anti-FHOD1 antibodies confirmed the presence of FHOD1 in intercalated discs and double immunostaining demonstrated its colocalisation with cadherin, plakoglobin and shifted localization to connexin43. PMID: 25555464
    4. Report FODH1 expression in cardiomyocytes and increased expression in dilated cardiommyopathy. PMID: 25125170
    5. FHOD1 promotes formation of short actin filaments and transiently associates with transverse arcs providing tight temporal and spatial control of the formation and turnover of transverse arcs into mature ventral stress fibers during dynamic cell behavior. PMID: 24481812
    6. the diaphanous formin FHOD1 as an interaction partner of N2G PMID: 24880667
    7. FHOD1 participates in cytoskeletal changes in epithelial-mesenchymal transition. PMID: 24086398
    8. Cdh1 contributes to spatiotemporal organization of AurB activity, and organization of FHOD1 activity by AurB contributes to daughter cell spreading after mitosis. PMID: 23613471
    9. FHOD1 stabilizes actin filaments by protecting barbed ends from depolymerization with its dimeric FH2 domain, whereas the region N-terminal to the FH1 domain mediates F-actin bundling by simultaneously binding to the sides of adjacent F-actin filaments. PMID: 23444374
    10. SIRPalpha/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen. PMID: 22490440
    11. FHOD1 and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR-200c. Expression levels of FHOD1 and PPM1F were inversely correlated with miR-200c level in breast cancer cell lines and breast cancer patient samples. PMID: 22144583
    12. Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets. PMID: 21605332
    13. FHOD1 is a critical regulator of smooth muscle cell phenotype and is regulated by ROCK-dependent phosphorylation. PMID: 21106951
    14. FHOS mediates an interaction between GLUT4/IRAP (insulin-responsive aminopeptidase) -containing vesicles and the cytoskeleton and may participate in exocytosis and/or retention of this membrane compartment PMID: 12677009
    15. Fhos directly binds to F-actin via the N-terminal region, forms a homotypic complex via the FH2 domain to organize actin cytoskeleton PMID: 14576350
    16. FHOD1 has a role in cyclic GMP-dependent inhibition of vascular smooth muscle cell stress fiber formation and/or migration PMID: 15051728
    17. Oligomerization of FHOD1 via the coiled-coil motif is a critical parameter for its biological activities. PMID: 15642356
    18. Sustained cell elongation is a consequence of FHOD1-mediated actin-microtubule coordination. PMID: 15878344
    19. These novel data demonstrate that FHOD1-ERK MAP kinase interaction regulates key aspects of FHOD1 biology. PMID: 16112087
    20. in FHOD1, DAD acts as signal sequence for binding to the well folded and monomeric FH3 domain PMID: 16361249
    21. This study demonstrates FHOD1 is cleaved by caspase-3 at the SVPD(616) site during apoptosis and the C-terminal FHOD1 cleavage product has the ability to inhibit RNA polymerase I transcription. PMID: 17013756
    22. In this study, the N-terminal region (residues 1-339) of the human formin homology domain-containing protein 1 (FHOD1) was purified and crystallized. PMID: 17909294
    23. FHOD1 is activated through phosphorylation by rho-dependent protein kinase (ROCK)and has an important function in stress fibre formation in vascular endothelial cells PMID: 18239683
    24. The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. PMID: 18694941
    25. Mutation of one residue in the predicted DAD-interaction surface efficiently activates FHOD1 in cells. PMID: 18786395

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.
  • 蛋白家族：
    Formin homology family
  • 组织特异性：
    Ubiquitous. Highly expressed in spleen.
  • 数据库链接：

    HGNC: 17905

    OMIM: 606881

    KEGG: hsa:29109

    STRING: 9606.ENSP00000258201

    UniGene: Hs.95231