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FEZF1 Antibody

  • 货号：
    CSB-PA008602LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U251 whole cell lysate
      All lanes: FEZF1 antibody at 6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 53, 47, 52 kDa
      Observed band size: 53 kDa
    • IHC image of CSB-PA008602LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FEZF1 Polyclonal antibody
  • Uniprot No.：
    A0PJY2
  • 基因名：
    FEZF1
  • 别名：
    FEZ antibody; FEZ family zinc finger 1 antibody; Fez family zinc finger protein 1 antibody; fez like antibody; fezf1 antibody; FEZF1_HUMAN antibody; Zinc finger protein 312 like antibody; Zinc finger protein 312B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Fez family zinc finger protein 1 protein (1-115AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FEZF1 Antibody (CSB-PA008602LA01HU)，的标记方式是Non-conjugated。对于FEZF1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008602LB01HU FEZF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA008602LC01HU FEZF1 Antibody, FITC conjugated
    Biotin CSB-PA008602LD01HU FEZF1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.
  • 基因功能参考文献：
    1. FEZF1 was significantly increased in glioma tissues. Over-expressed FIZF1 was associated with reduced survival. PMID: 30030762
    2. loss of FEZF1 impairs the pluripotency exit of hESCs during neural specification, which partially explains the neural induction defect caused by FEZF1 deletion. PMID: 29318501
    3. FEZF1plays a novel role in regulating the malignant behavior of glioma stem cells as a part of Linc00152/miR-103a-3p/FEZF1/CDC25A axis.FEZF1 up-regulated the promoter activities and bound to the promoters of CDC25A in glioma stem cells. PMID: 28651608
    4. High expression of long noncoding RNA FEZF1 was significantly associated with later stage and higher grade of gastric cancer. PMID: 29239821
    5. SEZ6L, HISPPD1, FEZF1, SAMD11 gene variants may be associated with autism spectrum disorder. PMID: 26204995
    6. Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. [Review] PMID: 24913420
    7. Mutations in FEZF1 cause Kallmann syndrome. PMID: 25192046
    8. the aberrant expression of ZNF312b promotes gastric tumorigenesis through epigenetic modification of its promoter region and provides a molecular mechanism for ZNF312b expression to contribute to the progression of gastric cancer. PMID: 21170990
    9. Study is the first to report that ZNF312b, a novel transcription factor, was associated with tumorigenicity of gastric cancer. PMID: 19318583
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19401682

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  • 相关疾病：
    Hypogonadotropic hypogonadism 22 with or without anosmia (HH22)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues.
  • 数据库链接：

    HGNC: 22788

    OMIM: 613301

    KEGG: hsa:389549

    STRING: 9606.ENSP00000411145

    UniGene: Hs.553970