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FEV Antibody

  • 货号：
    CSB-PA030145
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q99581
  • 基因名：
    FEV
  • 别名：
    ETS-domain transcription factor antibody; FEV (ETS oncogene family) antibody; FEV antibody; FEV ETS transcription factor antibody; FEV_HUMAN antibody; Fifth Ewing sarcoma variant antibody; Fifth Ewing variant protein antibody; HSRNAFEV antibody; mPet1 antibody; PC12 ETS domain-containing transcription factor 1 antibody; PC12 ETS factor 1 antibody; Pet-1 antibody; Protein FEV antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human FEV.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
  • 基因功能参考文献：
    1. This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents. PMID: 28846959
    2. identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin PMID: 27807368
    3. Genetic variation in FEV1 was associated with serum 25-Hydroxyvitamin D status. PMID: 26122139
    4. novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation PMID: 24100022
    5. Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development. PMID: 23591790
    6. our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders PMID: 20480378
    7. FEV identifies serotonin-producing cells in normal and neoplastic small intestine. PMID: 20048018
    8. Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. PMID: 19707175
    9. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. PMID: 12761502
    10. We showed that fev is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT transporter (sert) and tryptophan hydroxylase (tph), two markers of the 5-HT neurotransmitter system. PMID: 15003288
    11. Analysis of transgene expression in Pet-1 null mice indicates that Pet-1 is required to maintain the activity of the Pet-1 enhancer region in a subset of serotonin (5-HT) neurons. PMID: 15758173
    12. Variation in FEV gene observed exclusively in a subset of African American sudden infant death syndrome cases may help explain the observed abnormalities of this system in some SIDS cases and the ethnic disparity. PMID: 17597646

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  • 相关疾病：
    Sudden infant death syndrome (SIDS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
  • 数据库链接：

    HGNC: 18562

    OMIM: 272120

    KEGG: hsa:54738

    STRING: 9606.ENSP00000295727

    UniGene: Hs.234759