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FCRL2 Antibody

  • 货号：
    CSB-PA853454ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA853454ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA853454ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FCRL2 Polyclonal antibody
  • Uniprot No.：
    Q96LA5
  • 基因名：
    FCRL2
  • 别名：
    CD307b antibody; Fc receptor homolog 2 antibody; Fc receptor like protein 2 antibody; Fc receptor-like protein 2 antibody; FcR-like protein 2 antibody; FcRH2 antibody; FCRL 2 antibody; FcRL2 antibody; FCRL2_HUMAN antibody; IFGP family protein 4 antibody; IFGP4 antibody; Immunoglobulin receptor translocation associated 4 protein antibody; Immunoglobulin receptor translocation-associated protein 4 antibody; IRTA4 antibody; SH2 domain containing phosphatase anchor protein 1 antibody; SH2 domain-containing phosphatase anchor protein 1 antibody; SPAP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Fc receptor-like protein 2 protein (20-100AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May have an regulatory role in normal and neoplastic B cell development.
  • 基因功能参考文献：
    1. decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to rheumatoid arthritis inflammatory processes. PMID: 27193470
    2. FCRL2 overexpression in B cells from Hashimoto and Graves disease patients compared to normal subjects. PMID: 25738996
    3. a negative immunomodulatory function for FCRL2 in the regulation of memory B cells. PMID: 21068405
    4. B-CLL patients with high FCRL2 expression had a significantly longer treatment-free survival & overall survival than those with low FCRL2. PMID: 19682311
    5. FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in chronic lymphocytic leukemia. PMID: 18314442
    6. Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia. PMID: 18704934
    7. Down-regulation of FCRL2 is associated with acute lymphoblastic leukemia. PMID: 18802695

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone
  • 数据库链接：

    HGNC: 14875

    OMIM: 606509

    KEGG: hsa:79368

    STRING: 9606.ENSP00000355157

    UniGene: Hs.437393