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FCHO2 Antibody

  • 货号：
    CSB-PA606615LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, U251 whole cell lysate
      All lanes: FCHO2 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 89, 44, 86 kDa
      Observed band size: 89, 86 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA606615LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FCHO2 Polyclonal antibody
  • Uniprot No.：
    Q0JRZ9
  • 基因名：
    FCHO2
  • 别名：
    FCHO2F-BAR domain only protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human F-BAR domain only protein 2 protein (100-203AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FCHO2 Antibody (CSB-PA606615LA01HU)，的标记方式是Non-conjugated。对于FCHO2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA606615LB01HU FCHO2 Antibody, HRP conjugated ELISA
    FITC CSB-PA606615LC01HU FCHO2 Antibody, FITC conjugated
    Biotin CSB-PA606615LD01HU FCHO2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
  • 基因功能参考文献：
    1. Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement. PMID: 27237791
    2. The central linker of FCHO proteins acts as an allosteric regulator of the prime endocytic adaptor, AP-2. PMID: 25303365
    3. FCHO2 regulates the size of clathrin structures, and its interaction with Dab2 is needed for LDLR endocytosis under conditions of low AP2. PMID: 22323290
    4. show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub PMID: 22484487
    5. This structure shows a distant relationship to curvature-sensing BAR modules, and suggests how similar coiled-coil architectures in the BAR superfamily have evolved to expand the repertoire of membrane-sculpting possibilities PMID: 17540576

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  • 亚细胞定位：
    Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    FCHO family
  • 数据库链接：

    HGNC: 25180

    OMIM: 613438

    KEGG: hsa:115548

    STRING: 9606.ENSP00000393776

    UniGene: Hs.165762