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FBXW4 Antibody

  • 货号：
    CSB-PA008525ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008525ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA008525ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXW4 Polyclonal antibody
  • Uniprot No.：
    P57775
  • 基因名：
    FBXW4
  • 别名：
    FBXW4 antibody; FBW4 antibody; SHFM3 antibody; F-box/WD repeat-containing protein 4 antibody; Dactylin antibody; F-box and WD-40 domain-containing protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-box/WD repeat-containing protein 4 protein (143-412AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
  • 基因功能参考文献：
    1. biochemical characterization of the novel F-box and WD40 containing protein, FBXW4 PMID: 23658844
    2. a complex rearrangement associated with a approximately 0.5 Mb tandem duplication ion containing a disrupted extra copy of the DACTYLIN gene and the entire LBX1 and beta-TRCP genes. PMID: 12913067
    3. results indicate that genomic rearrangement of SHFM3 is rare among non-syndromic SHFM patients and emphasize the importance of screening for genomic rearrangements even in sporadic cases of SHFM PMID: 16235095
    4. Genomic rearrangements involving the SHFM3 locus at chromosome 10q24 is associated with syndromic and non-syndromic split-hand/foot malformation PMID: 16761290
  • 相关疾病：
    Split-hand/foot malformation 3 (SHFM3)
  • 组织特异性：
    Expressed in brain, kidney, lung and liver.
  • 数据库链接：

    HGNC: 10847

    OMIM: 246560

    KEGG: hsa:6468

    STRING: 9606.ENSP00000373698

    UniGene: Hs.500822