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FBXW2 Antibody

  • 货号：
    CSB-PA008524GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKT8
  • 基因名：
    FBXW2
  • 别名：
    F box and WD 40 domain containing protein 2 antibody; F box and WD repeat domain containing 2 antibody; F box and WD40 domain protein 2 antibody; F box/WD repeat containing protein 2 antibody; F-box and WD-40 domain-containing protein 2 antibody; F-box/WD repeat-containing protein 2 antibody; FBW 2 antibody; FBW2 antibody; FBXW 2 antibody; Fbxw2 antibody; FBXW2_HUMAN antibody; Fwd2 antibody; Md6 antibody; Protein MD6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human FBXW2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
  • 基因功能参考文献：
    1. BTrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation. PMID: 28090088
    2. RACK1 competes with GCM1 for FBW2 and thereby prevents GCM1 ubiquitination, which is also supported by the observation that GCM1 is destabilized in RACK1-knockdown BeWo placental cells PMID: 23651062
    3. the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system PMID: 15640526
    4. UBE2D2 is required for GCMa ubiquitination and for association with the SCF(FBXW2) complex. PMID: 18703417
  • 数据库链接：

    HGNC: 13608

    OMIM: 609071

    KEGG: hsa:26190

    STRING: 9606.ENSP00000363036

    UniGene: Hs.494985