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FBXW12 Antibody

  • 货号：
    CSB-PA751062LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA751062LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA751062LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXW12 Polyclonal antibody
  • Uniprot No.：
    Q6X9E4
  • 基因名：
    FBXW12
  • 别名：
    FBXW12 antibody; FBW12 antibody; FBXO12 antibody; FBXO35F-box/WD repeat-containing protein 12 antibody; F-box and WD-40 domain-containing protein 12 antibody; F-box only protein 35 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-box/WD repeat-containing protein 12 protein (1-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FBXW12 Antibody (CSB-PA751062LA01HU)，的标记方式是Non-conjugated。对于FBXW12 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA751062LB01HU FBXW12 Antibody, HRP conjugated ELISA
    FITC CSB-PA751062LC01HU FBXW12 Antibody, FITC conjugated
    Biotin CSB-PA751062LD01HU FBXW12 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
  • 基因功能参考文献：
    1. FBXW12 gene is deleted in approximately ten percent of the epithelial ovarian cancer cases studied; such deletions comprised either the FBXW12 promoter or the mRNA-encoding region. PMID: 26617728
    2. FBXW12 functions as an E3 ligase constituent to ubiquitinate and degrade IL-22R and that therapeutic FBXW12 inhibition may enhance IL-22 signaling and bolster mucosal host defense and infection containment. PMID: 26171402
    3. FBXO35 gene had a ubiquitously low expression pattern in most human adult tissues. FBXO35 gene was found located in chromosome 3p21. PMID: 15040455
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 20729

    OMIM: 609075

    KEGG: hsa:285231

    STRING: 9606.ENSP00000296438

    UniGene: Hs.288793