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FBXW10 Antibody

  • 货号：
    CSB-PA726395LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA726395LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA726395LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXW10 Polyclonal antibody
  • Uniprot No.：
    Q5XX13
  • 基因名：
    FBXW10
  • 别名：
    FBXW10 antibody; F-box/WD repeat-containing protein 10 antibody; F-box and WD-40 domain-containing protein 10 antibody; Ubiquitin ligase-specificity factor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-box/WD repeat-containing protein 10 protein (701-1000AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FBXW10 Antibody (CSB-PA726395LA01HU)，的标记方式是Non-conjugated。对于FBXW10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA726395LB01HU FBXW10 Antibody, HRP conjugated ELISA
    FITC CSB-PA726395LC01HU FBXW10 Antibody, FITC conjugated
    Biotin CSB-PA726395LD01HU FBXW10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
  • 基因功能参考文献：
    1. O-GlcNAcylation is involved in the regulation of ubiquitination-related genes including FBXW10 PMID: 23899520
    2. Mislocalized lamins can induce ubiquitin-mediated proteasomal degradation of certain HP1 isoforms by activation of FBXW10, a member of the F-box family of proteins that is involved in E3 ubiquitin ligase activity. PMID: 20498703
  • 数据库链接：

    HGNC: 1211

    OMIM: 611679

    KEGG: hsa:10517

    STRING: 9606.ENSP00000379026

    UniGene: Hs.592128