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FBLN2 Antibody

  • 货号：
    CSB-PA002533
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using Fibulin-2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P98095
  • 基因名：
    FBLN2
  • 别名：
    Fbln2 antibody; FBLN2_HUMAN antibody; FIBL-2 antibody; Fibulin-2 antibody; OTTHUMP00000216670 antibody; OTTHUMP00000216671 antibody; OTTHUMP00000216672 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Fibulin-2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.
  • 基因功能参考文献：
    1. Using in vitro approaches and cultured breast cancer cell lines s demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 than it is for ADAMTS-4. Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells. PMID: 28099917
    2. levels of fibulin 2 dramatically increased in the retinal pigment epithelium following retinal detachment, suggesting a direct role for fibulin 2 in the re-attachment of the retina to the retinal pigment epithelium. PMID: 24692557
    3. Study identified and validated a novel bona fide target of miR-1, Fibullin-2 (Fbln2), a secreted protein implicated in extracellular matrix remodeling. PMID: 23612897
    4. Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension. PMID: 22912785
    5. Data provide evidence that FBLN2 short isoform (FBLN2S) has an important tumor-suppressive and anti-angiogenic role in nasopharyngeal carcinoma (NPC). PMID: 21743496

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibulin family
  • 组织特异性：
    Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.
  • 数据库链接：

    HGNC: 3601

    OMIM: 135821

    KEGG: hsa:2199

    STRING: 9606.ENSP00000384169

    UniGene: Hs.198862