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FAT4 Antibody

  • 货号：
    CSB-PA740927LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA740927LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAT4 Polyclonal antibody
  • Uniprot No.：
    Q6V0I7
  • 基因名：
    FAT4
  • 别名：
    Cadherin family member 14 antibody; Cadherin related family member 11 antibody; CDHF14 antibody; CDHR11 antibody; FAT atypical cadherin 4 antibody; FAT J antibody; FAT tumor suppressor homolog 4 antibody; Fat-like cadherin protein FAT-J antibody; FAT4 antibody; FAT4_HUMAN antibody; FATJ antibody; hFat4 antibody; HKLLS2 antibody; Nbla00548 antibody; Protocadherin Fat 4 antibody; Putative protein product of Nbla00548 antibody; VMLDS2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protocadherin Fat 4 protein (4658-4862AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FAT4 Antibody (CSB-PA740927LA01HU)，的标记方式是Non-conjugated。对于FAT4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA740927LB01HU FAT4 Antibody, HRP conjugated ELISA
    FITC CSB-PA740927LC01HU FAT4 Antibody, FITC conjugated
    Biotin CSB-PA740927LD01HU FAT4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
  • 基因功能参考文献：
    1. The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
    2. Study shows that when key regulators during mammalian cerebral cortical development are disrupted due to DCHS1-FAT4 mutations, functional cerebral asymmetries are stronger. PMID: 25930014
    3. Epigenetic inactivation of FAT4 contributes to gastric field cancerization. PMID: 26792292
    4. In hepatocellular carcinoma patients, both FAT4 expression and FAT4 mutational status significantly correlated with patient prognosis. FAT4 acts as a putative tumor suppressor that is frequently inactivated in human hepatocellular carcinoma. PMID: 26672766
    5. In conclusion, Fat4 expression is deceased in gastric cancer cells, leading to nuclear translocation of Yap and correlates with poor prognosis. PMID: 26575609
    6. FAT4 has a tumour suppressor role mediated by the modulation of Wnt/beta-catenin signalling, providing potential novel targets for the treatment of gastric cancer PMID: 26633557
    7. our results reveal a novel inhibitory mechanism of FAT4 gene expression through actin depolymerization during Src-induced carcinogenesis in human breast cells. PMID: 25679223
    8. These findings suggest that Fat and Dachsous self-bend due to the loss of Ca(2+)-binding amino acids from specific EC-EC linkers, and can therefore adapt to confined spaces. PMID: 25355906
    9. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A. PMID: 24349473
    10. Homozygosity mapping and whole-exome sequencing was used in the original Hennekam syndrome family with multiple affected individuals in whom no CCBE1 mutation had been detected, and identified a homozygous mutation in the FAT4 gene. PMID: 24913602
    11. findings show that mutations in genes encoding the receptor-ligand cadherin pair DCHS1 and FAT4 lead to a recessive syndrome in humans that includes periventricular neuronal heterotopia PMID: 24056717
    12. The atypical cadherin Fat4 encodes at least part of the stromal cell differentiation signal. PMID: 23974041
    13. the nonsynonymous variants rs1014867 (Pro4972Ser) and rs1039808 (Ala807Val) of FAT4 may contribute to esophageal cancer susceptibility PMID: 23319386
    14. Recurrent somatic mutations in FAT4 gene is associated with gastric adenocarcinoma. PMID: 22484628
    15. Fat4 may be a breast tumor suppressor gene PMID: 19048595

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  • 相关疾病：
    Van Maldergem syndrome 2 (VMLDS2); Hennekam lymphangiectasia-lymphedema syndrome 2 (HKLLS2)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.
  • 数据库链接：

    HGNC: 23109

    OMIM: 612411

    KEGG: hsa:79633

    STRING: 9606.ENSP00000377862

    UniGene: Hs.563205