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FASTK Antibody

  • 货号：
    CSB-PA002483
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using FAST Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q14296
  • 基因名：
    FASTK
  • 别名：
    Fas activated serine threonine kinase antibody; Fas-activated serine/threonine kinase antibody; FAST antibody; FAST kinase antibody; FASTK antibody; FASTK_HUMAN antibody; FLJ13079 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human FAST.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.; Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
  • 基因功能参考文献：
    1. FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis. PMID: 25704814
    2. MIR-106a-5p functions as a tumor suppressor during the development of astrocytomas by targeting FASTK. PMID: 24013584
    3. FAST expression on lung cells of hematopoietic origin is crucial in mediating lipopolysaccharide-induced neutrophil migration to the lung in transgenic FAST-deficient mice compared with wild type controls. PMID: 20363972
    4. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1 regulated changes in protein expression. PMID: 15572676
    5. FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing PMID: 17135269
    6. Nuclear FAST can regulate the splicing of FGFR2 transcripts. PMID: 17592127

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  • 亚细胞定位：
    [Isoform 4]: Mitochondrion matrix.
  • 蛋白家族：
    FAST protein kinase family
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 24676

    OMIM: 606965

    KEGG: hsa:10922

    STRING: 9606.ENSP00000297532

    UniGene: Hs.647094