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FAM96B Antibody

  • 货号：
    CSB-PA897544ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FAM96B antibody at 7.23µg/ml
      Lane 1: Mouse gonadal tissue
      Lane 2: MCF-7 whole cell lysate
      Lane 3: Hela whole cell lysate
      Lane 4: K562 whole cell lysate
      Lane 5: A375 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 18 kDa
      Observed band size: 18 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA897544ESR1HU at dilution of 1:100
    • Immunoprecipitating FAM96B in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA897544ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA897544ESR1HU (4µg) + Hela whole cell lysate (500µg)
      Lane 3: Hela whole cell lysate (20µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAM96B Polyclonal antibody
  • Uniprot No.：
    Q9Y3D0
  • 基因名：
    FAM96B
  • 别名：
    CGI 128 antibody; FAM96B antibody; Family with sequence similarity 96; member B antibody; HSPC118 antibody; Hypothetical protein LOC51647 antibody; MIP18 antibody; MIP18_HUMAN antibody; Mitotic spindle-associated MMXD complex subunit MIP18 antibody; MSS19-interacting protein of 18 kDa antibody; Protein FAM96B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Mitotic spindle-associated MMXD complex subunit MIP18 protein (1-163AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.
  • 基因功能参考文献：
    1. Data suggest that CIA2B and MMS19 physically interact with C-terminus of viperin/RSAD2; CIAO1 appears to function as primary viperin-interacting protein; CIA2A binds to N-terminus of viperin in CIAO1-, CIA2B-, and MMS19-independent fashion. (CIA2B = metallochaperone CIA2B/FAM96B; MMS19 = transcription factor MMS19; CIAO1 = cytosolic iron-sulfur assembly component 1; CIA2A = metallochaperone CIA2A/Fam96a) PMID: 28615450
    2. CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization. PMID: 23891004
    3. Co-localization experiments by fluorescent confocal microscopy revealed that FAM96B colocalized with prelamin A in HEK-293 cells. PMID: 24041693
    4. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. PMID: 23150669
    5. these findings suggest that FAM96B acts as a regulator of E2-2 through the control of its protein expression. PMID: 21722264

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
  • 蛋白家族：
    MIP18 family
  • 数据库链接：

    HGNC: 24261

    OMIM: 614778

    KEGG: hsa:51647

    STRING: 9606.ENSP00000387471

    UniGene: Hs.9825