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FAIM Antibody

  • 货号：
    CSB-PA889122LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FAIM antibody at 2μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Rat gonad tissue
      Lane 3: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 21, 25, 23 kDa
      Observed band size: 21 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA889122LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA889122LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAIM Polyclonal antibody
  • Uniprot No.：
    Q9NVQ4
  • 基因名：
    FAIM
  • 别名：
    FAIM 1 antibody; Faim antibody; FAIM1 antibody; FAIM1_HUMAN antibody; Fas apoptotic inhibitory molecule 1 antibody; Fas apoptotic inhibitory molecule antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Fas apoptotic inhibitory molecule 1 protein (1-179AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FAIM Antibody (CSB-PA889122LA01HU)，的标记方式是Non-conjugated。对于FAIM Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA889122LB01HU FAIM Antibody, HRP conjugated ELISA
    FITC CSB-PA889122LC01HU FAIM Antibody, FITC conjugated
    Biotin CSB-PA889122LD01HU FAIM Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
  • 基因功能参考文献：
    1. the anti-apoptotic effect of SRT1720 was mitigated by FAIM knockdown with a small interfering RNA-targeted FAIM. These results indicated that pretreatment with SRT1720 improves survival of aged hMSCs, and enhances their therapeutic efficacy for rat myocardial infarction (MI). PMID: 28383554
    2. subcellular fractionation experiments revealed that, in contrast to FAIM-S and FAIM-L, FAIM-S_2a and FAIM-L_2a are able to localize to the nucleus, where they may have additional functions. In summary, here we report on two novel FAIM isoforms that may have relevant roles in the physiology and pathology of the nervous system PMID: 28981531
    3. Data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis. PMID: 26866272
    4. FAIM modulates IGF-1-induced Akt activation and IRF4 expression and has a role in multiple myeloma cell survival PMID: 23138182
    5. FAIM (1-90) was crystallized and diffracted to a resolution of 2.5 A; the crystal belonged to space group P3(1), with unit-cell parameters a=b=58.02, c=71.11 A, alpha=beta=90, gamma=120 degrees. PMID: 20693673
    6. Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection. PMID: 17912957
    7. Expression of the long form of Fas apoptotic inhibitory molecule (FAIML) results in the protection of neurons from the cytotoxic actions of death ligands. PMID: 17942717
    8. FAIM acts to specifically enhance CD40 signaling for NF-kappaB activation, IRF-4 expression, and BCL-6 down-regulation in vitro, but has no effect on its own PMID: 19592656

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    FAIM1 family
  • 数据库链接：

    HGNC: 18703

    OMIM: 617535

    KEGG: hsa:55179

    STRING: 9606.ENSP00000342805

    UniGene: Hs.173438