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F2RL2 Antibody

  • 货号：
    CSB-PA008165
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O00254
  • 基因名：
  • 别名：
    F2RL2; PAR3; Proteinase-activated receptor 3; PAR-3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PAR-3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
  • 基因功能参考文献：
    1. PAR3 is essential in thrombin stimulated insulin secretion. PMID: 26742564
    2. TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production. PMID: 26729042
    3. These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR activation, such as the activation of vascular-protective Tie2 by noncanonical PAR3 activation. PMID: 25320242
    4. In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav. PMID: 24699825
    5. Elevated expression of PAR-3, but not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients. PMID: 23739922
    6. A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C cytoprotective effects. PMID: 23788139
    7. PAR-3 receptors interact with thrombin and increase heme oxygenase-1 expression in synovial fibroblasts. PMID: 22541814
    8. Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR, whereas transcriptional control involves nuclear factor of activated T cells (NFAT). PMID: 21596928
    9. FXa bound in a punctate manner to thrombi under shear, while thrombin and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi PMID: 20454680
    10. genetic polymorphism is associated with peripheral arterial disease severity PMID: 20390230
    11. A novel role is identified for PAR3 in thrombin signaling. PMID: 20442298
    12. Down-regulation of connexin and par-3 signals early anaplasia and malignant change in rectal cancer. PMID: 19513616
    13. upregulated thrombin generation and inhibition of fibrinolysis, occurred in one-third of the Stem cell transplant patients associating with the development of Graft versus host disease PMID: 19718071
    14. Lower plasma levels of thrombin-antithrombin complex correlate to higher recanalisation rates after ischaemic stroke PMID: 19806263
    15. PAR-3 is expressed in human SMC and triggers intracellular calcium signaling. PMID: 14515192
    16. expression of PAR3 mRNA and protein in cells undergoing megakaryocytic maturation suggests a developmental role for PAR3; regulation of PAR3 expression appears to be specifically coupled to the protein kinase C system. PMID: 15504554
    17. a Na-independent Cl-/HCO3- exchange mechanism mediates the recovery of pHi from alkalosis in platelets and that thrombin activates this exchanger by a direct regulatory pathway PMID: 15850610
    18. The changes in levels of blood coagulation factor ii in folic acid deficient rats are reversed by treatment with folic acid. PMID: 16046705
    19. F2R genetic variants may influence the natural history of CHD in patients at high risk of cardiovascular events. PMID: 17347481
    20. PAR-3 is able to signal autonomously to induce IL-8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses PMID: 18264801
    21. Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. PMID: 18836030
    22. This study demonstrates that the anticoagulant profile of thrombin often caused by a mutation of the thrombin scaffold finds its likely molecular origin in the stabilization of the inactive E* form. PMID: 19473969
    23. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. PMID: 19586901

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
  • 数据库链接：

    HGNC: 3539

    OMIM: 601919

    KEGG: hsa:2151

    STRING: 9606.ENSP00000296641

    UniGene: Hs.42502