EYA2 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) EYA2 Polyclonal antibody
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Uniprot No.:O00167
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基因名:EYA2
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别名:EAB 1 antibody; EAB1 antibody; EYA 2 antibody; EYA transcriptional coactivator and phosphatase 2 antibody; EYA2 antibody; EYA2_HUMAN antibody; eyes absent 2 homolog (Drosophila) antibody; Eyes absent homolog 2 (Drosophila) antibody; Eyes absent homolog 2 antibody; Translation of this uORF probably lowers the translation efficiency of EYA2 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Eyes absent homolog 2 protein (1-514AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,EYA2 Antibody (CSB-PA007907LA01HU),的标记方式是Non-conjugated。对于EYA2 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organog...显示更多
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基因功能参考文献:
- our data indicate that Eya2 may serve as a potential oncoprotein in human astrocytoma. Eya2 regulates astrocytoma cell proliferation and invasion, possibly through the regulation of ERK signaling. PMID: 28901379
- EYA2 knockdown led to decreased metastatic spread of breast cancer cells to the lung and greatly attenuated the ability of EGFR to regulate the epithelial-to-mesenchymal transition markers. PMID: 28703807
- High EYA2 expression is associated with acute myeloid leukemia. PMID: 28416638
- EYA2 functions as a stimulant in lung adenocarcinoma pathogenesis. PMID: 26329363
- results demonstrate that overexpression of miR-30a in lung adenocarcinoma A549 cells can inhibit cell migration and invasion, which is partially attributed to the decrease of EYA2 expression PMID: 26837415
- SIX1 and EYA are often co-overexpressed in tumors, and the SIX1-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model. PMID: 25555392
- Decreased expression of EYA2 is associated with pancreatic adenocarcinomas. PMID: 24810906
- This interaction suggests that CDK6 regulates EYA2 activity, a mechanism that could be important in development and in cancer. PMID: 24196439
- MIR30A represses Eya2 expression by binding to the 3'-untranslated region of Eya2.The MIR30A/EYA2 axis regulates breast cancer cell proliferation and migration. PMID: 24508260
- Functional roles of candidate genes EYA2 (20q13) and hsa-miR-375 (2q35) were studied by siRNA-mediated knock-down and overexpression, respectively, in hrHPV-containing cell lines. PMID: 22987659
- Given that SIX1 and EYA are overexpressed in many tumor types, our data indicate that targeting the SIX1-EYA complex may be a potent approach to inhibit tumor progression in multiple cancer types PMID: 23435380
- Studies indicate that the RNA and protein levels of Eya2 is upregulated in ovarian cancer. PMID: 22607316
- Data implicate Eya2 as a necessary co-factor for many of the metastasis promoting functions of Six1. PMID: 21706047
- Expression of EYA2 in lung adenocarcinoma is augmented. PMID: 19950702
- Based on observation that the dachshund-binding site is located between the catalytic core & Sine Oculis binding sites within ED-Eya2, we propose that catalytic activity can be translated to SO binding through DAC, which acts as a transcriptional switch. PMID: 19858093
- EYA2 was found to function as transcriptional activator in ovarian cancer cells by Gal4 assay and to promote tumor growth in vivo in xenograft models. PMID: 15705892
- EYA2 and EYA3 displayed specificity for Tyr-142 of H2A.X PMID: 19351884
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亚细胞定位:Cytoplasm. Nucleus.
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蛋白家族:HAD-like hydrolase superfamily, EYA family
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组织特异性:Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
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数据库链接:
HGNC: 3520
OMIM: 601654
KEGG: hsa:2139
STRING: 9606.ENSP00000333640
UniGene: Hs.472877