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EYA2 Antibody

  • 货号：
    CSB-PA007907LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007907LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EYA2 Polyclonal antibody
  • Uniprot No.：
    O00167
  • 基因名：
    EYA2
  • 别名：
    EAB 1 antibody; EAB1 antibody; EYA 2 antibody; EYA transcriptional coactivator and phosphatase 2 antibody; EYA2 antibody; EYA2_HUMAN antibody; eyes absent 2 homolog (Drosophila) antibody; Eyes absent homolog 2 (Drosophila) antibody; Eyes absent homolog 2 antibody; Translation of this uORF probably lowers the translation efficiency of EYA2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Eyes absent homolog 2 protein (1-514AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EYA2 Antibody (CSB-PA007907LA01HU)，的标记方式是Non-conjugated。对于EYA2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007907LB01HU EYA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA007907LC01HU EYA2 Antibody, FITC conjugated
    Biotin CSB-PA007907LD01HU EYA2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
  • 基因功能参考文献：
    1. our data indicate that Eya2 may serve as a potential oncoprotein in human astrocytoma. Eya2 regulates astrocytoma cell proliferation and invasion, possibly through the regulation of ERK signaling. PMID: 28901379
    2. EYA2 knockdown led to decreased metastatic spread of breast cancer cells to the lung and greatly attenuated the ability of EGFR to regulate the epithelial-to-mesenchymal transition markers. PMID: 28703807
    3. High EYA2 expression is associated with acute myeloid leukemia. PMID: 28416638
    4. EYA2 functions as a stimulant in lung adenocarcinoma pathogenesis. PMID: 26329363
    5. results demonstrate that overexpression of miR-30a in lung adenocarcinoma A549 cells can inhibit cell migration and invasion, which is partially attributed to the decrease of EYA2 expression PMID: 26837415
    6. SIX1 and EYA are often co-overexpressed in tumors, and the SIX1-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model. PMID: 25555392
    7. Decreased expression of EYA2 is associated with pancreatic adenocarcinomas. PMID: 24810906
    8. This interaction suggests that CDK6 regulates EYA2 activity, a mechanism that could be important in development and in cancer. PMID: 24196439
    9. MIR30A represses Eya2 expression by binding to the 3'-untranslated region of Eya2.The MIR30A/EYA2 axis regulates breast cancer cell proliferation and migration. PMID: 24508260
    10. Functional roles of candidate genes EYA2 (20q13) and hsa-miR-375 (2q35) were studied by siRNA-mediated knock-down and overexpression, respectively, in hrHPV-containing cell lines. PMID: 22987659
    11. Given that SIX1 and EYA are overexpressed in many tumor types, our data indicate that targeting the SIX1-EYA complex may be a potent approach to inhibit tumor progression in multiple cancer types PMID: 23435380
    12. Studies indicate that the RNA and protein levels of Eya2 is upregulated in ovarian cancer. PMID: 22607316
    13. Data implicate Eya2 as a necessary co-factor for many of the metastasis promoting functions of Six1. PMID: 21706047
    14. Expression of EYA2 in lung adenocarcinoma is augmented. PMID: 19950702
    15. Based on observation that the dachshund-binding site is located between the catalytic core & Sine Oculis binding sites within ED-Eya2, we propose that catalytic activity can be translated to SO binding through DAC, which acts as a transcriptional switch. PMID: 19858093
    16. EYA2 was found to function as transcriptional activator in ovarian cancer cells by Gal4 assay and to promote tumor growth in vivo in xenograft models. PMID: 15705892
    17. EYA2 and EYA3 displayed specificity for Tyr-142 of H2A.X PMID: 19351884

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    HAD-like hydrolase superfamily, EYA family
  • 组织特异性：
    Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
  • 数据库链接：

    HGNC: 3520

    OMIM: 601654

    KEGG: hsa:2139

    STRING: 9606.ENSP00000333640

    UniGene: Hs.472877