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  4. EXTL2 Antibody

EXTL2 Antibody

  • 中文名称：
    EXTL2兔多克隆抗体
  • 货号：
    CSB-PA007903GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBQ6
  • 基因名：
    EXTL2
  • 别名：
    4-N-acetylhexosaminyltransferase EXTL2 antibody; Alpha 1 4 N acetylhexosaminyltransferase EXTL2 antibody; Alpha 1 antibody; Alpha GalNAcT EXTL2 antibody; Alpha-1 antibody; Alpha-GalNAcT EXTL2 antibody; Exostoses (multiple) like 2 antibody; Exostoses multiple like 2 antibody; Exostosin like 2 antibody; Exostosin like glycosyltransferase 2 antibody; EXT L2 antibody; EXT related protein 2 antibody; EXT-related protein 2 antibody; EXTL 2 antibody; EXTL2 antibody; EXTL2_HUMAN antibody; EXTR 2 antibody; EXTR2 antibody; Glucuronyl galactosyl proteoglycan 4 alpha N acetylglucosaminyltransferase antibody; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody; Multiple exostoses like 2 antibody; Processed exostosin like 2 antibody; Processed exostosin-like 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EXTL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
  • 基因功能参考文献：
    1. EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for proteoglycans PMID: 23395820
    2. Lysosomal glycosaminoglycan levels in mucopolysaccharidosis are reduced by EXTL2 gene silencing. PMID: 19690583
    3. donor binding appears to undergo two distinct steps, beginning with the N-acetyl group expelling water from the donor- enzyme complex into the bulk solvent followed by positioning of the donor into the binding site for interactions with the enzyme PMID: 15831490
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed exostosin-like 2]: Secreted. Note=A soluble form is found in the serum.
  • 蛋白家族：
    Glycosyltransferase 47 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 3516

    OMIM: 602411

    KEGG: hsa:2135

    STRING: 9606.ENSP00000359131

    UniGene: Hs.357637