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EXD2 Antibody

  • 货号：
    CSB-PA873662LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Mouse stomach tissue
      All lanes: EXD2 antibody at 2.8μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 71, 57 kDa
      Observed band size: 71 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA873662LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA873662LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EXD2 Polyclonal antibody
  • Uniprot No.：
    Q9NVH0
  • 基因名：
    EXD2
  • 别名：
    4930539P14Rik antibody; C14orf114 antibody; C85658 antibody; DKFZp781A0133 antibody; DKFZp781L15100 antibody; Exd2 antibody; EXD2_HUMAN antibody; EXDL2 antibody; Exonuclease 3''-5'' domain-containing protein 2 antibody; Exonuclease 3''-5'' domain-like-containing protein 2 antibody; exonuclease 3'-5' domain-like 2 antibody; FLJ10738 antibody; RGD1311087 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Exonuclease 3\'-5\' domain-containing protein 2 protein (137-245AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EXD2 Antibody (CSB-PA873662LA01HU)，的标记方式是Non-conjugated。对于EXD2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873662LB01HU EXD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA873662LC01HU EXD2 Antibody, FITC conjugated
    Biotin CSB-PA873662LD01HU EXD2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:10000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation.
  • 基因功能参考文献：
    1. establish that EXD2 stimulates both short- and long-range DSB resection PMID: 26807646
  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion matrix. Nucleus. Chromosome.
  • 蛋白家族：
    EXD2 family
  • 数据库链接：

    HGNC: 20217

    OMIM: 616940

    KEGG: hsa:55218

    STRING: 9606.ENSP00000313140

    UniGene: Hs.533878