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ESYT1 Antibody

  • 中文名称：
    ESYT1兔多克隆抗体
  • 货号：
    CSB-PA008278GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BSJ8
  • 基因名：
    ESYT1
  • 别名：
    E Syt1 antibody; E-Syt1 antibody; Esyt1 antibody; ESYT1_HUMAN antibody; Extended synaptotagmin 1 antibody; Extended synaptotagmin like protein 1 antibody; Extended synaptotagmin-1 antibody; FAM62A antibody; Family with sequence similarity 62 (C2 domain containing) member A antibody; Family with sequence similarity 62 member A antibody; KIAA0747 antibody; MBC2 antibody; Membrane bound C2 domain containing protein antibody; Membrane-bound C2 domain-containing protein antibody; Protein FAM62A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human FAM62A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
  • 基因功能参考文献：
    1. a main effect of Ca(2+) on E-Syt1 is to reverse an autoinhibited state and to couple membrane tethering with lipid transport. PMID: 29222176
    2. knockdown of ESYT1 (and family members ESYT2 and ESYT3) significantly decreased ANO1 current density. PMID: 29154949
    3. This study identified and confirmed ESYT1 protein changes within the postsynaptic density in schizophrenia. PMID: 25048004
    4. ESyt2 and ESyt3, but not ESyt1, interact with activated FGFR1. PMID: 25922075
    5. The extended synaptotagmins (E-Syt1, E-Syt2, and E-Syt3) are endoplasmic reticulum-anchored proteins. They form homo- and heteromeric complexes that mediate contacts with the plasma membrane. Such contacts are critically dependent on the presence of PI(4,5)P2 in this membrane and are additionally regulated by cytosolic Ca2+ via the Ca2+-sensing property of E-Syt1. PMID: 23791178
    6. E-Syt1 is a mediator of cancer cell invasion. PMID: 22659450

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Extended synaptotagmin family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 29534

    KEGG: hsa:23344

    STRING: 9606.ENSP00000267113

    UniGene: Hs.632729