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ESX1 Antibody

  • 中文名称：
    ESX1兔多克隆抗体
  • 货号：
    CSB-PA007838GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N693
  • 基因名：
  • 别名：
    ESX1 antibody; ESX1L antibody; ESX1R antibody; Homeobox protein ESX1 antibody; Extraembryonic antibody; spermatogenesis antibody; homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human ESX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
  • 基因功能参考文献：
    1. ESX1 mRNA level decreases as the severity of spermatogenic defects increase in non-obstructive azoospermic men. PMID: 25316452
    2. ESX1 emerges as a potentially reliable molecular marker of residual spermatogenesis in azoospermic men PMID: 20356899
    3. proteolytic processing of ESXR1 plays a role in concerted regulation of the cell cycle and transcription in human cells PMID: 15235584
    4. ESX1L is expressed during all stages of placental development and is localized to sparse areas of trophoblast in terminal villi in association with cytotrophoblastic cells PMID: 15601583
    5. In FGR-affected placentae, ESX1L levels were lower than in gestation-matched controls, indicating a potential role for the ESX1L gene within the growth control mechanism of the fetus, through its effect on placental function. PMID: 16613891

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
  • 组织特异性：
    Expressed in placenta and testis. Expressed in testicular germ cell tumors.
  • 数据库链接：

    HGNC: 14865

    OMIM: 300154

    KEGG: hsa:80712

    STRING: 9606.ENSP00000361669

    UniGene: Hs.223782