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ESRP2 Antibody

  • 货号：
    CSB-PA007833LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: ESRP2 antibody at 6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 79, 78 kDa
      Observed band size: 79 kDa
    • IHC image of CSB-PA007833LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA007833LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA007833LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ESRP2 Polyclonal antibody
  • Uniprot No.：
    Q9H6T0
  • 基因名：
    ESRP2
  • 别名：
    Epithelial splicing regulatory protein 2 antibody; ESRP 2 antibody; ESRP2 antibody; ESRP2_HUMAN antibody; FLJ21918 antibody; FLJ22248 antibody; RBM35B antibody; RNA binding motif protein 35A antibody; RNA binding motif protein 35B antibody; RNA binding protein 35B antibody; RNA-binding motif protein 35B antibody; RNA-binding protein 35B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Epithelial splicing regulatory protein 2 protein (615-720AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ESRP2 Antibody (CSB-PA007833LA01HU)，的标记方式是Non-conjugated。对于ESRP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007833LB01HU ESRP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA007833LC01HU ESRP2 Antibody, FITC conjugated
    Biotin CSB-PA007833LD01HU ESRP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
  • 基因功能参考文献：
    1. In conclusion, our findings suggested that IFNG-AS1 may function as an oncogene in pituitary adenoma by interacting with ESRP2. PMID: 30322807
    2. Findings define a direct role for ESRP2 in the generation of conserved repertoires of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes. PMID: 26531099
    3. functions of the ESRP2 in an epithelial posttranscriptional gene expression program. PMID: 22354987
    4. ESRP2 coordinates a complex alternative splicing network that adds an important post-transcriptional layer to the changes in gene expression that underlie epithelial-mesenchymal transitions during development and disease. PMID: 20711167
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ESRP family
  • 组织特异性：
    Epithelial cell-specific.
  • 数据库链接：

    HGNC: 26152

    OMIM: 612960

    KEGG: hsa:80004

    STRING: 9606.ENSP00000418748

    UniGene: Hs.436585