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ERH Antibody

  • 货号：
    CSB-PA02745A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA02745A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ERH Polyclonal antibody
  • Uniprot No.：
    P84090
  • 基因名：
    ERH
  • 别名：
    DROER antibody; Enhancer of rudimentary homolog (Drosophila) antibody; Enhancer of rudimentary homolog antibody; ERH antibody; ERH_HUMAN antibody; FLJ27340 antibody; HGNC:3447 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Enhancer of rudimentary homolog protein (2-104AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ERH Antibody (CSB-PA02745A0Rb)，的标记方式是Non-conjugated。对于ERH Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA02745B0Rb ERH Antibody, HRP conjugated ELISA
    FITC CSB-PA02745C0Rb ERH Antibody, FITC conjugated
    Biotin CSB-PA02745D0Rb ERH Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May have a role in the cell cycle.
  • 基因功能参考文献：
    1. Data suggest that ERH interacts directly in nucleus with C-terminal Arg-Gly-rich region of SAFB1/SAFB2 and this multimer co-localizes in insoluble nuclear fraction; binding of ERH reverses inhibition exerted by SAFB1/SAFB2 on SRPK1. (ERH = enhancer of rudimentary homolog protein; SAFB = scaffold attachment factor B; SRPK1 = splicing kinase SR protein kinase-1) PMID: 28627136
    2. ERH regulation of RNA processing is needed to ensure faithful DNA replication and repair. PMID: 26100022
    3. REVIEW: recent findings indicate that ERH plays an important role in cell cycle through its mRNA splicing activity and is critically required for genomic stability and cancer cell survival PMID: 24078386
    4. Identification of amino acid residues of ERH required for its recruitment to nuclear speckles and replication foci PMID: 24015320
    5. Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. PMID: 23236152
    6. ERH contributes to chromosome alignment at the metaphase plate by localizing CENP-E at kinetochore regions. PMID: 22704934
    7. molecular structure, dimerization and protein-protein interactions PMID: 15794639
    8. ERH may be an important transcription regulator that also functions in the control of cell-cycle progression. PMID: 17444515
    9. interaction with ERH could block the binding of p21(Cip1/Waf1) by Ciz1 in the cell. When ERH and Ciz1 are coexpressed in HeLa cells, Ciz1 recruits ERH to DNA replication foci PMID: 18081865
    10. Enhancer of rudimentary homolog (ERH) overexpression may be implicated in the initiation and/or progression of certain human malignancies. PMID: 18500978

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    E(R) family
  • 组织特异性：
    Expressed in all tissues examined.
  • 数据库链接：

    HGNC: 3447

    OMIM: 601191

    KEGG: hsa:2079

    STRING: 9606.ENSP00000451080

    UniGene: Hs.509791