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ERCC3 Antibody

  • 货号：
    CSB-PA007771GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P19447
  • 基因名：
  • 别名：
    Basic transcription factor 2 89 kDa subunit antibody; BTF 2 antibody; BTF2 antibody; BTF2 p89 antibody; DNA excision repair protein ERCC-3 antibody; DNA repair protein complementing XP-B cells antibody; ERCC 3 antibody; ercc3 antibody; ERCC3_HUMAN antibody; Excision Repair Cross-complementing Rodent Repair deficiency complementation Group 3 antibody; GTF2H antibody; RAD 25 antibody; RAD25 antibody; TFIIH 89 kDa subunit antibody; TFIIH antibody; TFIIH basal transcription factor complex 89 kDa subunit antibody; TFIIH basal transcription factor complex helicase XPB subunit antibody; TFIIH p89 antibody; Xeroderma pigmentosum group B-complementing protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ERCC3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
  • 基因功能参考文献：
    1. This study demonstrates that CpG-specific DNA methylation in the ERCC3 promoter region may be involved in benzene-induced epigenetic modification and it may contribute to benzene-induced hematotoxicity. PMID: 28813025
    2. An essential role of MYC-ERCC3 interactions in PDAC. PMID: 27384421
    3. similar to tumors arising in the background of homologous repair defects, mutations in nucleotide excision repair genes such as ERCC3 could constitute potential therapeutic targets in a subset of hereditary breast cancers. PMID: 27655433
    4. results reveal a previously unknown role for transcription factor IIH in ATR kinase activation in non-replicating, non-cycling cells PMID: 28592488
    5. Study shows that: mRNA synthesis is sensitive to the inhibition of the ATPase activity of XPB; mRNA synthesis accommodates the depletion of XPB; XPB-depleted TFIIH participates in mRNA synthesis, and finally, XPB ATPase overcomes transcription initiation block imposed by its helicase motifs. PMID: 28157507
    6. findings suggest that benzene exposure may be associated with hypermethylation in ERCC3, and that genetic variants in EPHX1 may play an important role in epigenetic changes and hematotoxicity among benzene-exposed workers PMID: 23797950
    7. The crystal structure of the C-terminal half of the XPB subunit of TFIIH (residues 494-782) is reported, containing XPB helicase domain (HD)2 and a C-terminal extension which shares structural similarity with RIG-I. PMID: 23385459
    8. Phenotype-specific adverse effects of XPD mutations on human prenatal development implicate impairment of TFIIH-mediated functions in placenta. PMID: 22234153
    9. reduction in ERCC3 by siRNA interference in human melanocytes in vitro reduced their tyrosinase production ability PMID: 22615732
    10. These results indicated that persistent HBV infection might trigger NER impairment in part through upregulation of miR-192, which suppressed the levels of ERCC3 and ERCC4. PMID: 21672525
    11. Results show that a deficiency in functional XPB paradoxically renders cells more sensitive to the genotoxic effects of oxidative stress while reducing the cytotoxic effects. PMID: 19840190
    12. The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. PMID: 21157430
    13. The C1D gene has been identified as one of the major genes whose expression is significantly upregulated by restoring XPB function. PMID: 20530579
    14. results demonstrated that a) XP-G/CS mutations affect the disassembly state of TFIIH resulting in the dissociation of CAK, but not XPD from core TFIIH PMID: 20543986
    15. TFIIH core subunit p89, but not other subunits of TFIIH, associates with the centrosomes and the adjacent parts of the mitotic spindle during mitosis. PMID: 20208140
    16. p52 mediates function within the transcription/repair factor TFIIH. PMID: 12080057
    17. Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. PMID: 12393803
    18. TFIIH from trichothiodystrophy patients, but not from xeroderma pigmentosum patients, exhibit a significant in vitro basal transcription defect in addition to a reduced intercellular concentration. PMID: 12820975
    19. High XRB mRNA levels is associated with Clear cell tumors of epithelial ovarian cancer PMID: 14614013
    20. identification of a new, evolutionarily conserved, core TFIIH subunit is essential for our understanding of TFIIH function in transcription, DNA repair and human disease PMID: 15220921
    21. Reduced expression of ERCC3 was correlated with esophageal cancer progression PMID: 15375507
    22. data support an additional role for XPB in promoting the incision of the damaged DNA fragment and reveal a point of nucleotide excision repair regulation on TFIIH without interference in its transcription activity PMID: 15549133
    23. Single Nucleotide Polymorphism in the ERCC3 is associated with lung cancer PMID: 16835333
    24. XPB could inhibit the proliferation of hepatoma cells and had a positive effect on the expression of p53 and p21(waf1/cip1) but a negative effect on c-myc. PMID: 16914395
    25. Multiple proteins both known and unknown to interact with RAD52 were identified by the "dual-tagging" proteomic method. PMID: 19338310
    26. Single Nucleotide Polimorphisms in VEGF and ERCC3 were associated with alterations in White Blood Cells and WBC subtype counts in workers exposed to benzene, even at relatively low levels of exposure below 1 ppm. PMID: 19773279

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  • 相关疾病：
    Xeroderma pigmentosum complementation group B (XP-B); Trichothiodystrophy 2, photosensitive (TTD2)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Helicase family, RAD25/XPB subfamily
  • 数据库链接：

    HGNC: 3435

    OMIM: 133510

    KEGG: hsa:2071

    STRING: 9606.ENSP00000285398

    UniGene: Hs.469872