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  4. ERBIN Antibody

ERBIN Antibody

  • 货号：
    CSB-PA857021ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: VSX1 antibody IgG at 0.87μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 159, 154, 153, 152, 151, 147, 160 kDa
      Observed band size: 159 kDa
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA857021ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA857021ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ERBIN Polyclonal antibody
  • Uniprot No.：
    Q96RT1
  • 基因名：
  • 别名：
    Densin-180-like protein antibody; Erbb2-interacting protein antibody; Erbb2ip antibody; Erbin antibody; LAP2 antibody; LAP2_HUMAN antibody; Protein LAP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Erbin protein (1193-1412AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion.
  • 基因功能参考文献：
    1. Our data uncovered an important role of Erbin in regulating hepatocellular carcinoma (HCC) tumorigenesis through inactivating ERalpha-mediated tumor-suppressive signaling, suggesting a new strategy for tamoxifen therapy in HCC by targeting Erbin/ERalpha signaling axis. PMID: 28192186
    2. STAT3 activation promotes ERBIN expression and negatively regulates TGF-beta activity by the formation of a STAT3-ERBIN-SMAD2/3 complex. PMID: 28126831
    3. Erbin loss accelerates cell cycle though down-regulating p21 and p27 expression. Erbin is a novel negative modulator of Akt1-Skp2-p27 signaling pathway. PMID: 26025650
    4. Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor PMID: 25521828
    5. Erbin is an ErbB2 regulator for breast tumor formation and progression PMID: 25288731
    6. analysis of the C-terminal ligand specificity of the erbin PDZ domain PMID: 24813123
    7. Data reveal that Erbin is a negative regulator of AKT activation and suggest that Erbin may play a role in breast cancer progression. PMID: 23711387
    8. DSG1 and Erbin cooperate to repress MAPK signaling and promote keratinocyte differentiation. PMID: 23524970
    9. These results unravel a critical role of c-Myb in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression. PMID: 22880131
    10. Data conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2beta regulates motility of cancer cells and suggest that LAP2beta may have utility for diagnostics and therapeutics in digestive tract cancers. PMID: 22745766
    11. ERBIN binds to SARA using a domain (amino acids 1208-1265) that also interacts with SMAD2 and SMAD3, which we have called the SSID (SARA- and SMAD-interacting domain) PMID: 21878490
    12. PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF PMID: 11821434
    13. interacts in vivo with p0071 and may be involved in the organization of adherens junctions and the desmosomes of epithelia PMID: 12047349
    14. Erbin is a novel suppressor of Ras signaling by disrupting the Ras-Raf interaction; a negative regulator of the Ras-Raf-Erk signaling pathway PMID: 12379659
    15. selective binding and sequestration of this residue in its unphosphorylated state by the Erbin PDZ provides a novel mechanism for regulation of the ErbB2-mediated signaling and oncogenicity PMID: 12444095
    16. In this review, erbin is shown to inhibit epidermal growth factor signaling by preventing the activation of the Raf-1 kinase by Ras. PMID: 12966186
    17. Erbin is a regulator of Nod2-dependent NF-kappaB signaling with a role in inflammatory responses PMID: 16203728
    18. Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction PMID: 16301319
    19. Structural analyses reveal that the differences between Erbin PDZ domain and the first PDZ domain of ZO-1 in specificity can be accounted for by two key differences in primary sequence. PMID: 16737969
    20. ErbB2, APC, beta-catenin, c-Rel and HTLV-1 Tax were identified as ligands of the PDZ domain of Erbin. PMID: 17100642
    21. Results define Erbin as a novel negative modulator of Smad2/Smad3 functions and expand the physiological role of Erbin to the regulation of TGFbeta signaling. PMID: 17591701
    22. Both palmitoylation and leucine-rich repeats are required for the plasma membrane localization of ERBIN. PMID: 18498353
    23. erbin acts as a negative regulator of beta-catenin/T-cell-factor-dependent gene expression. An erbin mutant with a deletion of the N-terminal leucine-rich repeat allows the PDZ domain of erbin to increase beta-catenin/T-cell-factor-dependent transcription PMID: 18667832
    24. Arginine 279, glutamic acid 246 in Smad3 and glutamic acid 1321 in Erbin are important for these proteins binding. PMID: 19013433
    25. This review discusses all-intracellular and membrane-associated localization of Densin-180 and its signaling, including a phosphorylation-rich area. PMID: 19187442

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  • 亚细胞定位：
    Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane.
  • 蛋白家族：
    LAP (LRR and PDZ) protein family
  • 组织特异性：
    Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
  • 数据库链接：

    HGNC: 15842

    OMIM: 606944

    KEGG: hsa:55914

    STRING: 9606.ENSP00000370330

    UniGene: Hs.591774