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ERAP2 Antibody

  • 中文名称：
    ERAP2兔多克隆抗体
  • 货号：
    CSB-PA007761GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6P179
  • 基因名：
    ERAP2
  • 别名：
    ERAP2 antibody; LRAPEndoplasmic reticulum aminopeptidase 2 antibody; EC 3.4.11.- antibody; Leukocyte-derived arginine aminopeptidase antibody; L-RAP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human ERAP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
  • 基因功能参考文献：
    1. this study shows the association of ERAP2 single nucleotide polymorphism and its haplotypes with psoriasis vulgaris, and its dependence on the presence or absence of the HLA-C*06:02 allele and age at disease onset PMID: 29183862
    2. These results indicated that the ERAP gene may play a critical role in HCV chronicity in this Chinese Han population PMID: 29037997
    3. ERAP2 deficiency causes increased MHC class I free heavy chain expression and up-regulation of the unfolded protein response pathway in anklyosing spondylitis. PMID: 28029742
    4. ERAP-2 significantly influences the B*27:05-bound peptidome by destroying some ligands and decreasing the abundance of many more ligands with N-terminal basic residues, while increasing the abundance of nonamers. The former effects are best explained by direct ERAP-2 trimming. The effects on peptide length might be attributed to ERAP-2-induced activation of ERAP-1 trimming. These data support the notion of a peptide-media PMID: 27110896
    5. study reveals fine-mapped AID risk variants that act as eQTLs with ERAP2 in thymus PMID: 27829666
    6. Increased expression of ERAP2 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis. PMID: 27384923
    7. ERAP2 is associated with ankylosing spondylitis in HLA-B27 positive and HLA-B27 negative patients. PMID: 25917849
    8. ERAP2 might be associated with CLNM in PTMC. PMID: 26148615
    9. ERAP2 variation does not have a significant effect on PBMC intracellular and cell surface HLA-class I expression and heavy chain formation, markers of ER stress or inflammatory cytokine production. PMID: 26088389
    10. The risk allele of the polymorphism near ERAP2 is strongly associated with birdshot chorioretinopathy. PMID: 24957906
    11. ERAP2 haplotype A is correlated with resistance to HIV-1 infection, possibly secondarily to its effect on antigen processing and presentation. PMID: 23435305
    12. The association and co-localization of ERAP2 and EpCAM at the surface of breast cancer cells is a unique and novel finding that provides new ideas on EpCAM processing and on how antigen presentation may be regulated in cancer. PMID: 23988446
    13. Generation and destruction of antigenic peptides by endoplasmic reticulum resident aminopeptidases ERAP1 and ERAP2 have been shown in the last few years to be important for correct functioning and regulation of the adaptive immune response. PMID: 23545452
    14. The common ERAP2 single nucleotide polymorphism rs2549782 that codes for amino acid variation Asp392Lys leads to alterations in both the activity and the specificity of the enzyme. PMID: 22837489
    15. crystals of ERAP2 belonged to an orthorhombic space group and diffracted anisotropically to 3.3 A resolution in the best direction on an in-house X-ray source PMID: 22505422
    16. The molecular structure of glycosylated human ERAP2 has been determined to 3.08 A resolution by molecular replacement using ERAP1 as a search model and refined. PMID: 22106953
    17. assessed frequency of rs2248374 SNP in ERAP2 in ankylosing spondylitis (AS) cases and controls and found no association with AS PMID: 21719416
    18. strong evidence that ERAP2 plays a role in the development of preeclampsia PMID: 21569342
    19. ERAP2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
    20. Data show that the differences between the ERAP2 splice forms provide important insights into the potential mechanism for the action of selection. PMID: 20976248
    21. ERAP2, which encodes an aminopeptidase, did not show preferential parent-of-origin expression, but rather, cis-acting nonimprinted differential allelic control PMID: 18369178
    22. Novel preeclampsia risk locus, ERAP2, in a region of known genetic linkage to this pregnancy-specific disorder. PMID: 19578876
    23. Dramatic genetic effect on LRAP expression. PMID: 17129607

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase M1 family
  • 组织特异性：
    Ubiquitously expressed. Highly expressed in spleen and leukocytes.
  • 数据库链接：

    HGNC: 29499

    OMIM: 609497

    KEGG: hsa:64167

    STRING: 9606.ENSP00000400376

    UniGene: Hs.482910