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  4. ERAP1 Antibody

ERAP1 Antibody

  • 中文名称：
    ERAP1兔多克隆抗体
  • 货号：
    CSB-PA698943
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA698943(ERAP1 Antibody) at dilution 1/466, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9NZ08
  • 基因名：
    ERAP1
  • 别名：
    A LAP antibody; A-LAP antibody; Adipocyte derived leucine aminopeptidase antibody; Adipocyte-derived leucine aminopeptidase antibody; ALAP antibody; Aminopeptidase PILS antibody; Aminopeptidase regulator of TNFR1 shedding antibody; APPILS antibody; ARTS 1 antibody; ARTS-1 antibody; Arts1 antibody; Endoplasmic reticulum aminopeptidase 1 antibody; Endoplasmic reticulum aminopeptidase associated with antigen processing antibody; ERAAP antibody; ERAAP1 antibody; ERAP 1 antibody; Erap1 antibody; ERAP1_HUMAN antibody; KIAA0525 antibody; kiaa0525 protein antibody; PILS AP antibody; PILS-AP antibody; PILSA antibody; PILSAP antibody; Puromycin insensitive leucyl specific aminopeptidase antibody; Puromycin-insensitive leucyl-specific aminopeptidase antibody; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator antibody; type 1 tumor necrosis factor receptors shedding aminopeptidase regulator antibody; VEGF-induced aminopeptidase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ERAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
  • 基因功能参考文献：
    1. There was a significant association between ERAP1 polymorphisms (rs30187 and rs27037) and increased risk of Ankylosing Spondylitis susceptibility. PMID: 30461632
    2. ERAP1 gene rs26653 polymorphism may increase the risk of psoriasis vulgaris in Chinese Han population PMID: 30313118
    3. this study shows the association of ERAP1 single nucleotide polymorphism and its haplotypes with psoriasis vulgaris, and its dependence on the presence or absence of the HLA-C*06:02 allele and age at disease onset PMID: 29183862
    4. ERAP1 and ERAP2 heterodimers have a role in mediating the processing pathway of MHC class I antigens PMID: 27514473
    5. these results indicated that the ERAP gene may play a critical role in Hepatitis C virus chronicity in Chinese Han population PMID: 29037997
    6. this study demonstrates associations of ERAP1 coding variants and domain specific interaction with HLA-C *06 in the early onset psoriasis patients of India PMID: 28867178
    7. To decrease the enzymatic activity of ERAP1. PMID: 28901420
    8. Data demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. PMID: 28746870
    9. these results present the first direct evidence that human disease-associated ERAP1 variants can greatly alter survival, as well as antigen presentation, T-cell repertoire and NK cell responses in vivo in mice PMID: 28814066
    10. The ERAP1 association with ankylosing spondylitis is predominantly attributable to common ERAP1 haplotypes and haplotype combinations. PMID: 28049827
    11. these study reports an association of the ERAP1 SNP rs30187 with the HLA-C*07 allele in inflammatory bowel disease in the Spanish population PMID: 28651467
    12. Study suggests that ERAP1 rs27044 polymorphism may be related to ankylosing spondylitis susceptibility in Chinese Han population. PMID: 29278768
    13. Segregating according to HLAB27 status did not alter the lack of association. rs30187 SNP in ERAP1 does not confer risk of developing ERA or AS in the Asian Indian population. PMID: 28161768
    14. ERAP1 and ERAP2 have significant and distinct effects on the HLA-B*27 peptidome, suggesting that both enzymes largely act as separate entities in vivo. This may explain their different patterns of association with AS. PMID: 28063628
    15. This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 and ERAP2 polymorphisms on their enzymatic activity. PMID: 28759104
    16. The ERAP1 gene polymorphism might be a risk factor in the pathogenesis of ankylosing spondylitis and inflammatory bowel disease. In contrast, IL-23R gene polymorphisms may serve a protective role in ankylosing spondylitis and inflammatory bowel disease. PMID: 27458846
    17. Our results suggest that normal levels of ERAP1 reduce the accumulation of aberrant and disulfide-linked forms of HLA-B27 in monocytes, and thus help to maintain the integrity of cell surface HLA-B27 complexes. PMID: 27107845
    18. The alterations in the nature and affinity of HLA-B*51.peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the joint association of ERAP1 and HLA-B*51 with Behcet's disease. PMID: 28446606
    19. One ERAP1 protein allotype with five non-ancestral amino acids was recessively associated with Behcet's disease. The ERAP1 association was absent in individuals who lacked HLA-B*51. Individuals who carry HLA-B*51 and who are also homozygous for the haplotype had an increased disease odds compared with those with neither risk factor. PMID: 27217550
    20. Electrostatic interactions between domains II and IV in ERAP1 are crucial for driving a conformational change that regulates the structural integrity of the catalytic site. PMID: 28218509
    21. analysis of genotype and haplotype frequencies of four coding, nonsynonymous ERAP1 SNPs, rs26653G > C, rs26618T > C, rs30187C > T, and rs27044C > G, in non-small cell lung carcinoma occurring in two genetically distant populations, Chinese and Poles PMID: 28083613
    22. there is a significant association of ERAP2 with psoriatic arthritis and HLA-B27 negative psoriatic arthritis, while ERAP1 association is restricted only to HLA-B27 positive disease PMID: 28083616
    23. The ERAP1 rs27044/rs30187 haplotype C/T is associated with lower risk of extraspinal disease and systemic inflammation in Nordic AS patients but has no impact on IL-6 or TNF levels. PMID: 27095091
    24. The ERAP1 polymorphisms are associated with the development of ankylosing spondylitis in Europeans and East Asians. [review & meta-analysis] PMID: 27108589
    25. ERAP1 gene rs27434 and rs7711564 polymorphisms may increase the risk of ankylosing spondylitis (AS). PMID: 26617903
    26. Suggest ERAP1 rs27434 SNP is associated with ankylosing spontylitis in Zhejiang Han Chinese population. PMID: 26350268
    27. Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis. PMID: 26130142
    28. ERAP-1 has a significant influence on the B*51:01 peptidome and its affinity which provides a mechanism for the epistatic association of ERAP-1 and B*51:01 in Behcet's disease. PMID: 26360328
    29. KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking PMID: 26321090
    30. beta2i/MECL-1 and PA28 negatively affect C- and N-terminal cleavage and therefore epitope liberation from the proteasome, whereas ERAP1 destroys the MART-1(26-35) epitope by overtrimming activity PMID: 26399368
    31. epistatic interaction between ERAP1 and the HLA class I alleles HLA-B*27 and HLA-B*40:01 affects susceptibility to ankylosing spondylitits PMID: 25994336
    32. The results reveal the nature of the functional interaction between A*29:02 and ERAP1 and suggest that this enzyme may affect the susceptibility to birdshot chorioretinopathy by altering the A*29:02 peptidome. PMID: 25892735
    33. ERAP1 downregulation is associated with loss of heterozygosity. PMID: 26146606
    34. Genetic variants and haplotypes of ERAP1 are associated with ankylosing spondylitis, psoriasis, and Behcet's disease in people of varying ancestries. PMID: 26002026
    35. CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 are bona fide susceptibility genes for Behcet's disease. PMID: 26097239
    36. We concluded that ERAP1 variants are associated with AS in East Asian population, indicating a common pathogenic mechanism for AS in East Asians and Caucasians. PMID: 25817437
    37. Meta-analysis. ERAP1 polymorphisms were associated with AS in Caucasians, but their association with AS in Asians needs further exploration. PMID: 25401226
    38. ERAP1 as being involved in modulating innate responses of human immune cells PMID: 25591727
    39. rs1065407 and rs10050860 of the ERAP1 gene may contribute to the genetic susceptibility of BD by modulating the expression of ERAP1. PMID: 26393469
    40. two of the most consistently discovered disease-associated polymorphisms, namely K528R and Q730E of ERAP1, were analyzed for their effect on the ability of the enzyme to select substrates based on length and to undergo conformational changes. PMID: 26224046
    41. Our data were consistent with an association between ERAP1 and Behcet disease as well as with an epistatic interaction between ERAP1 and HLA-B in the Spanish population. PMID: 25019531
    42. Data demonstrate that aberrant ERAP1 activity and HLA-B27 carriage does not alter endoplasmic reticulum stress levels in ankylosing spondylitis, suggesting that ERAP1 and HLA-B27 may influence disease susceptibility through other mechanisms. PMID: 25354578
    43. Spondyloarthritis-associated ERAP1 polymorphisms affect the level of gene expression in antigen-presenting cells. PMID: 25740711
    44. Studies indicate the critical role of M1 aminopeptidases ERAP1, ERAP2 and NPEPPS in immune-mediated diseases. PMID: 25142031
    45. Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to ERAP1. PMID: 25187574
    46. data suggest that ERAP1 isoforms may exhibit differential biological properties and inflammatory mediators could play critical roles in modulating ERAP1 expression, leading to altered functional activities of this enzyme. PMID: 25545008
    47. The 3'UTR-1008A>C and 3'UTR-1055A>G polymorphisms of ERAP1 gene are associated with essential hypertension. PMID: 25665737
    48. polymorphic ERAP1 alters protein function predisposing an individual to Ankylosing Spondylitis via its influence on the antigen processing pathway PMID: 25422414
    49. Genetic or pharmacological inhibition of ERAP1 on human tumor cell lines perturbs their ability to engage several classes of inhibitory receptors. PMID: 25592150
    50. The significant alterations in the B*27:05 peptidome and the structural features of the peptides that determine their differential expression in distinct ERAP1 contexts account for the association of the R528K polymorphism with AS PMID: 25469497

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase M1 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 18173

    OMIM: 606832

    KEGG: hsa:51752

    STRING: 9606.ENSP00000296754

    UniGene: Hs.666524